ID A0A0G3HAZ5_9CORY Unreviewed; 1032 AA.
AC A0A0G3HAZ5;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=CUTER_02655 {ECO:0000313|EMBL:AKK10546.1};
OS Corynebacterium uterequi.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1072256 {ECO:0000313|EMBL:AKK10546.1, ECO:0000313|Proteomes:UP000035548};
RN [1] {ECO:0000313|EMBL:AKK10546.1, ECO:0000313|Proteomes:UP000035548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45634 {ECO:0000313|EMBL:AKK10546.1,
RC ECO:0000313|Proteomes:UP000035548};
RX PubMed=26227590;
RA Ruckert C., Kriete M., Jaenicke S., Winkler A., Tauch A.;
RT "Virulence Factor Genes Detected in the Complete Genome Sequence of
RT Corynebacterium uterequi DSM 45634, Isolated from the Uterus of a Maiden
RT Mare.";
RL Genome Announc. 3:e00783-15(2015).
RN [2] {ECO:0000313|Proteomes:UP000035548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45634 {ECO:0000313|Proteomes:UP000035548};
RA Ruckert C., Albersmeier A., Winkler A., Tauch A.;
RT "Complete genome sequence of Corynebacterium uterequi DSM 45634, isolated
RT from the uterus of a maiden mare.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP011546; AKK10546.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G3HAZ5; -.
DR STRING; 1072256.CUTER_02655; -.
DR KEGG; cut:CUTER_02655; -.
DR PATRIC; fig|1072256.5.peg.526; -.
DR OrthoDB; 5240387at2; -.
DR Proteomes; UP000035548; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000035548}.
FT DOMAIN 10..304
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 269..565
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 674..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 31..38
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1032 AA; 110720 MW; 2D86981157D57E8B CRC64;
MGTEVSVSDG STPVRDWPAD LPLTGRWKVT GQSGSGVSSF LIDTVANRLA AGASPDGVLV
VATSKESAAG LRSGIHEQLL SRAGGASFVA EAPLVRSVHS LAFSLLRQVS DEPIRLITGA
EQDAIIRELL DIHAEHKQAV WPADVRPALR FLGFARQLRD LLLRAAERGQ SPEDLEELGR
RHARPLWTSA GTFLREYEQV MALSGTHRYS ASELLSRVLE EELPRDWHTV VVDDAQNLDP
HSAALIERIA PLGDDGLVVY GGNSEHAVFR FRGADAEVFE NIPGTLIDLG PSRRDPARRV
VRATSVSAEN ATVADAVRRA HLEQRVAWRD IAVIVRSTAQ IEAVRRTLLA AKVPVHVNPT
DIVLSEQHLV RTILLGLKAV TTGLTDSELL DVLLGPVGGA DPVTLRRLIR GLRRFAPAAR
GMDTLTSLVD STDALPDFGS TLTERELAIL NRMRRVLDAT RAAVDAGGSI EEVLWALWNA
TELATRLQTA ALRGGATGSQ ADRDLDAVMA LFDVAGDFVE RHPGGATIEA FVRHVREQEL
PTGVRDRRVA GPDAVRLLTA HGSLGREFDT VVVAGVQEET WPSLGETGSL FGQEELLDLL
DSDIEPGTPV SHTEARLQEE RRLFRVATTR ARRFLLVTCV QNVESNTPLE ASRFIEEFAA
ACELEIEEIG EPPAGATAAT EAASATDHDD APGAAVPGLL GPRILAPSSL IAELRRCVCD
PQARDDARRQ AARQLARLAA AGVPGAHPDS WASTTTASTE VPLRDLSRPA RLSPSKLEKL
LQCPLSAVLG SVEDEDHSRL AADRGTLAHA YFEAVANGVD QELARGLTCE AFAEILDEPQ
WRLASLKEDF AQLLGAIDAW LGAGGGRLEL VGTEVPVNVM VTDGVEIAGR IDRLDRDGDG
AVRIVDLKTA ASLPTKDAVQ ENLQLAAYQL ALSRGVLRQG RVVAAAEGGE PIRRAGAQLL
FPAQPDAKGQ PGRREQSALE PEFLAHFAAE LPAAVAALTG PELVAREGAH CQYCRISAIC
PVKLEGRVII NA
//
