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Database: UniProt
Entry: A0A0G3ILU8_9MYCO
LinkDB: A0A0G3ILU8_9MYCO
Original site: A0A0G3ILU8_9MYCO 
ID   A0A0G3ILU8_9MYCO        Unreviewed;       289 AA.
AC   A0A0G3ILU8;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000256|RuleBase:RU910714};
DE            Short=HIBADH {ECO:0000256|RuleBase:RU910714};
DE            EC=1.1.1.31 {ECO:0000256|RuleBase:RU910714};
GN   ORFNames=AB431_05845 {ECO:0000313|EMBL:AKK26296.1};
OS   Mycobacterium sp. EPa45.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1545728 {ECO:0000313|EMBL:AKK26296.1, ECO:0000313|Proteomes:UP000035237};
RN   [1] {ECO:0000313|Proteomes:UP000035237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPa45 {ECO:0000313|Proteomes:UP000035237};
RA   Kato H., Ogawa N., Ohtsubo Y., Ohshima K., Toyoda A., Yamazoe A., Mori H.,
RA   Maruyama F., Nagata Y., Hattori M., Fujiyama A., Kurokawa K., Tsuda M.;
RT   "Complete Genome Sequence of a Phenanthrene Degrader, Mycobacterium sp.
RT   Strain EPa45, Isolated from a Phenanthrene-Degrading Consortium.";
RL   Genome Announc.0:0-0(2015).
RN   [2] {ECO:0000313|EMBL:AKK26296.1, ECO:0000313|Proteomes:UP000035237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPa45 {ECO:0000313|EMBL:AKK26296.1,
RC   ECO:0000313|Proteomes:UP000035237};
RX   PubMed=26184940;
RA   Kato H., Ogawa N., Ohtsubo Y., Oshima K., Toyoda A., Mori H., Nagata Y.,
RA   Kurokawa K., Hattori M., Fujiyama A., Tsuda M.;
RT   "Complete Genome Sequence of a Phenanthrene Degrader, Mycobacterium sp.
RT   Strain EPa45 (NBRC 110737), Isolated from a Phenanthrene-Degrading
RT   Consortium.";
RL   Genome Announc. 3:e00782-15(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-
CC         oxopropanoate + H(+) + NADH; Xref=Rhea:RHEA:17681, ChEBI:CHEBI:11805,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57700,
CC         ChEBI:CHEBI:57945; EC=1.1.1.31;
CC         Evidence={ECO:0000256|RuleBase:RU910714};
CC   -!- PATHWAY: Amino-acid degradation; L-valine degradation.
CC       {ECO:0000256|RuleBase:RU910714}.
CC   -!- SIMILARITY: Belongs to the HIBADH-related family.
CC       {ECO:0000256|ARBA:ARBA00009080, ECO:0000256|RuleBase:RU910714}.
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DR   EMBL; CP011773; AKK26296.1; -; Genomic_DNA.
DR   RefSeq; WP_047329139.1; NZ_CP011773.1.
DR   AlphaFoldDB; A0A0G3ILU8; -.
DR   STRING; 1545728.AB431_05845; -.
DR   KEGG; mye:AB431_05845; -.
DR   PATRIC; fig|1545728.4.peg.1187; -.
DR   OrthoDB; 3185659at2; -.
DR   UniPathway; UPA00362; -.
DR   Proteomes; UP000035237; Chromosome.
DR   GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0006574; P:valine catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR011548; HIBADH.
DR   InterPro; IPR029154; HIBADH-like_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; TIGR01692; HIBADH; 1.
DR   PANTHER; PTHR22981:SF7; 3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   3: Inferred from homology;
KW   Branched-chain amino acid catabolism {ECO:0000256|ARBA:ARBA00022456,
KW   ECO:0000256|RuleBase:RU910714};
KW   NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU910714};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU910714}.
FT   DOMAIN          3..159
FT                   /note="6-phosphogluconate dehydrogenase NADP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03446"
FT   DOMAIN          162..287
FT                   /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF14833"
FT   ACT_SITE        168
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ   SEQUENCE   289 AA;  28996 MW;  CC543CBA56AB04BC CRC64;
     MTTIAFLGLG HMGGPMAANL VNAGYSVRGF DPVPALRAAA EAKGATVFEV GAAAVSEADV
     VITSLPNGGI VKACYAEALP AARPGTLFID TSTISVDDAR EVNAQASAAG MAQLDAPVSG
     GIKGATAGTL AFMVGGEADA LDKARPVLDP MASKVIHCGS SGAGQAAKLC NNMVLAVQQI
     AVGEAFVLAE KLGLSAQSLF DVITGATGNC WAVHTNCPVP GPVPTSPANN NFQPGFATAL
     MNKDLGLAMN AVSSTGATAP LGTHAAEIYA KFAEEHADLD FSAVIETLR
//
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