ID A0A0G3UJR6_9ACTN Unreviewed; 442 AA.
AC A0A0G3UJR6;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Ribonuclease {ECO:0000313|EMBL:AKL65956.1};
GN ORFNames=M444_11650 {ECO:0000313|EMBL:AKL65956.1};
OS Streptomyces sp. Mg1.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=465541 {ECO:0000313|EMBL:AKL65956.1, ECO:0000313|Proteomes:UP000035653};
RN [1] {ECO:0000313|EMBL:AKL65956.1, ECO:0000313|Proteomes:UP000035653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mg1 {ECO:0000313|EMBL:AKL65956.1,
RC ECO:0000313|Proteomes:UP000035653};
RX PubMed=23908282;
RA Hoefler B.C., Konganti K., Straight P.D.;
RT "De Novo Assembly of the Streptomyces sp. Strain Mg1 Genome Using PacBio
RT Single-Molecule Sequencing.";
RL Genome Announc. 1:e00535-13(2013).
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DR EMBL; CP011664; AKL65956.1; -; Genomic_DNA.
DR RefSeq; WP_047960563.1; NZ_CP011664.1.
DR AlphaFoldDB; A0A0G3UJR6; -.
DR KEGG; strm:M444_11650; -.
DR PATRIC; fig|465541.12.peg.2556; -.
DR OrthoDB; 5296884at2; -.
DR Proteomes; UP000035653; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR CDD; cd09279; RNase_HI_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR014636; RNaseH/PGlycerate_mutase.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR48100; BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED; 1.
DR PANTHER; PTHR48100:SF1; PHOSPHOGLYCERATE MUTASE PMU1-RELATED; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR Pfam; PF13456; RVT_3; 1.
DR PIRSF; PIRSF036922; RNaseH_PGAM; 1.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000035653}.
FT DOMAIN 3..142
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 208..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 246
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT ACT_SITE 322
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT BINDING 298
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 442 AA; 45670 MW; 74168AEBD6017299 CRC64;
MQRPLRFVVE ADGGSRGNPG PAGYGSVVLD PATGETLAER AEYIGVATNN VAEYKGLIAG
LKAARELAPD AQVLVRMDSK LVVEQMSGRW KIKHPDMKPL AAEAATVLPR SQVTYQWIPR
EQNKHADRLA NEAMDAGKHG RQWEPSASTA VFDRGAARAL ATPPAAGPPG DAAAGAAAVR
AALASASGTT ASAAASAPAE ADTLFAAEGS GAPEPAPAAA PGPTAAPASG WGPDMGTPAT
FVLLRHGETA LTPQKRFSGS GGTDPELSPA GRRQAAAVAE ALAARGTVQA VVSSPLRRCR
ETAQAVADRL GLAVVVEDGL RETDFGAWEG LTFGEVRERF PDDLQAWLDS PKAAPTGGGE
SFSAVTRRVS AARDRLLAAY AGRTVLVVTH VTPVKTLVRL ALGAPPESLF RMELSAASLS
AVAYYADGNA SVRLLNDTSH LR
//
