ID   A0A0G3V4W3_9ACTN        Unreviewed;       316 AA.
AC   A0A0G3V4W3;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Nucleoside-diphosphate-sugar epimerase {ECO:0000313|EMBL:AKL73922.1};
DE            EC=4.2.1.46 {ECO:0000313|EMBL:AKL73922.1};
GN   ORFNames=IMCC26256_111652 {ECO:0000313|EMBL:AKL73922.1};
OS   Actinobacteria bacterium IMCC26256.
OC   Bacteria; Actinomycetota; Actinomycetes.
OX   NCBI_TaxID=1650658 {ECO:0000313|EMBL:AKL73922.1, ECO:0000313|Proteomes:UP000035517};
RN   [1] {ECO:0000313|EMBL:AKL73922.1, ECO:0000313|Proteomes:UP000035517}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IMCC26256 {ECO:0000313|EMBL:AKL73922.1,
RC   ECO:0000313|Proteomes:UP000035517};
RA   Kim S.;
RT   "Genome sequencing of freshwater Actinobacteria.";
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|ARBA:ARBA00001911};
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DR   EMBL; CP011489; AKL73922.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G3V4W3; -.
DR   STRING; 1650658.IMCC26256_111652; -.
DR   KEGG; abai:IMCC26256_111652; -.
DR   PATRIC; fig|1650658.3.peg.1641; -.
DR   OrthoDB; 9801785at2; -.
DR   UniPathway; UPA00796; UER00771.
DR   Proteomes; UP000035517; Chromosome.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0048040; F:UDP-glucuronate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:InterPro.
DR   GO; GO:0033320; P:UDP-D-xylose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05230; UGD_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR044516; UXS.
DR   PANTHER; PTHR43078:SF6; UDP-GLUCURONIC ACID DECARBOXYLASE 1; 1.
DR   PANTHER; PTHR43078; UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:AKL73922.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035517}.
FT   DOMAIN          5..239
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
SQ   SEQUENCE   316 AA;  34990 MW;  572D9C4D594C12C3 CRC64;
     MPRAVVTGGS GFLGSHLCEY LLNRGYEVVA VDNLLTGRRS NISSLEGRDG FTFLQHDVIQ
     GIPVEGKVDC VLHFASPASP PEYLNLPFET LDVGSIGTRH ALELAHQNKA RFLMASTSEI
     YGDPLVHPQT EGYWGNVNTL GPRSVYDEAK RFSEALTMAY HRYHGLDTKI ARIFNTMGPR
     MKPSDGRVVS NFLVQAIEGN PLTIYGDGTQ TRSFCFVEDE VRGLVALMES DHIGAMNIGN
     PNEFTILELA EKVRDVCGSD AGIVFESLPE DDPVRRRPDI TLAKSVLGWS PEINLTEALE
     RTCKWYREEL AQAEAK
//