ID A0A0G3VI81_CHISP Unreviewed; 560 AA.
AC A0A0G3VI81;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Tyrosine hydroxylase long isoform {ECO:0000313|EMBL:AKL78848.1};
DE EC=1.14.16.2 {ECO:0000313|EMBL:AKL78848.1};
DE SubName: Full=Tyrosine hydroxylase protein 1 {ECO:0000313|EMBL:WNV48193.1};
GN Name=TH-L {ECO:0000313|EMBL:AKL78848.1};
OS Chilo suppressalis (Asiatic rice borer moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Pyraloidea;
OC Crambidae; Crambinae; Chilo.
OX NCBI_TaxID=168631 {ECO:0000313|EMBL:AKL78848.1};
RN [1] {ECO:0000313|EMBL:AKL78848.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu G., Wu S., Huang J., Ye G.;
RT "De novo assembly and characterization of central nervous system
RT transcriptome reveals neurotransmitter signaling systems in Chilo
RT suppressalis.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:WNV48193.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu Q.-Y.;
RT "Tyrosine hydroxylase plays crucial roles in larval cuticle formation and
RT larval-pupal tanning in the rice stem borer, Chilo suppressalis.";
RL Submitted (AUG-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR EMBL; KP657623; AKL78848.1; -; mRNA.
DR EMBL; OR472489; WNV48193.1; -; mRNA.
DR STRING; 168631.A0A0G3VI81; -.
DR OrthoDB; 275463at2759; -.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004511; F:tyrosine 3-monooxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR GO; GO:0042423; P:catecholamine biosynthetic process; IEA:InterPro.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR InterPro; IPR005962; Tyr_3_mOase.
DR InterPro; IPR019773; Tyrosine_3-monooxygenase-like.
DR NCBIfam; TIGR01269; Tyr_3_monoox; 1.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF15; TYROSINE 3-MONOOXYGENASE; 1.
DR Pfam; PF00351; Biopterin_H; 1.
DR PIRSF; PIRSF000336; TH; 1.
DR PRINTS; PR00372; FYWHYDRXLASE.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS00367; BH4_AAA_HYDROXYL_1; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE 2: Evidence at transcript level;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR000336-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR000336-1};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AKL78848.1}.
FT DOMAIN 209..555
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT REGION 56..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 388
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT BINDING 393
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT BINDING 433
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
SQ SEQUENCE 560 AA; 63409 MW; 6518F7EA40B1BB1E CRC64;
MAVAAAQKNR EMFAIKKSYS IENGYPSRRR SLVDDARFET LVVKQTKQSV LEEARARAND
SGLDSEFIQD GVPIGNGDNS PTVEDGTQQD ETKNGQLADA DIGDDASKTD EDYTLTEEEI
ILQNAASESP EAEQAIQQAA LLLRMRDGMG SLARVLKTVD NYKGCVQHLE TRPSQVTDVQ
FDALVKVSMS RNNLLQLIRS LRQSTAFAGV NLMTENISSK TPWFPRHASD LDNCNHLMTK
YEPELDMNHP GFADKEYRER RKQIAEIAFA YKYGDPIPSI SYKETENATW QRVFNTVLDL
MPKHACREYK AAFTKLQEAD IFVPHRIPQL EDVSNFLRKH TGFTLRPAAG LLTARDFLAS
LAFRVFQSTQ YVRHANSPFH TPEPDCIHEL LGHIPLLADP SFAQFSQEIG LASLGASDSE
IEKLSTVYWF TVEFGLCKEN HQLKAYGAAL LSSIGELLHA LSDKPELRPF EPASTSVQPY
QDQEYQPIYY VAESFEDAKD KFRRWVSAMS RPFEVRFNPH TERVEVLDTV DKLETLIWQL
NTEMLHLTNA VKKLKGTHFE
//
