ID A0A0G3WIM6_9BACT Unreviewed; 344 AA.
AC A0A0G3WIM6;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081,
GN ECO:0000313|EMBL:AKL98163.1};
GN ORFNames=Epro_0784 {ECO:0000313|EMBL:AKL98163.1};
OS Endomicrobium proavitum.
OC Bacteria; Elusimicrobiota; Endomicrobiia; Endomicrobiales;
OC Endomicrobiaceae; Endomicrobium.
OX NCBI_TaxID=1408281 {ECO:0000313|EMBL:AKL98163.1, ECO:0000313|Proteomes:UP000035337};
RN [1] {ECO:0000313|EMBL:AKL98163.1, ECO:0000313|Proteomes:UP000035337}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rsa215 {ECO:0000313|EMBL:AKL98163.1,
RC ECO:0000313|Proteomes:UP000035337};
RA Zheng H.;
RT "Complete genome sequence of Endomicrobium proavitum.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; CP009498; AKL98163.1; -; Genomic_DNA.
DR RefSeq; WP_052570702.1; NZ_CP009498.1.
DR AlphaFoldDB; A0A0G3WIM6; -.
DR STRING; 1408281.Epro_0784; -.
DR KEGG; epo:Epro_0784; -.
DR PATRIC; fig|1408281.3.peg.803; -.
DR OrthoDB; 9783139at2; -.
DR Proteomes; UP000035337; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000035337};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 111..327
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 344 AA; 39030 MW; 57E241EFE6E32A88 CRC64;
MRQVSIEIVK ERKANVLRAV IHHYIKTGKP VGSNVLIDEY KIKLSPATVR NLMAELEEEE
FLTHPHTSAG RIPTDKGYRA YVDSILKLQQ FAIAEEGRIK KEYEQKHNEI EAMLSETSRI
LSGLSQYTGF VLAPKTEYNE ITNIELVQIA PAQLLIILLT HTGMVKHRKI DASLTPEQLA
KLRIFLNERV RGVSLSEATS KIVSEMRKIK KDEEDIYKTA KKISDAFYAI HDDIYIDGTS
NTMEIPEFSD FGQVRSLVKL NEDKEKLIQI VNEDFSESGV HVKIGSENSL AELKDLSVVT
TVYKDGEKAV GVLGIIGPKR MEYERMMGLV NTVSQMLNEF FKKK
//
