ID A0A0G4EIF2_VITBC Unreviewed; 632 AA.
AC A0A0G4EIF2;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=formate--tetrahydrofolate ligase {ECO:0000256|ARBA:ARBA00012295};
DE EC=6.3.4.3 {ECO:0000256|ARBA:ARBA00012295};
GN ORFNames=Vbra_5021 {ECO:0000313|EMBL:CEL95783.1};
OS Vitrella brassicaformis (strain CCMP3155).
OC Eukaryota; Sar; Alveolata; Colpodellida; Vitrellaceae; Vitrella.
OX NCBI_TaxID=1169540 {ECO:0000313|EMBL:CEL95783.1, ECO:0000313|Proteomes:UP000041254};
RN [1] {ECO:0000313|EMBL:CEL95783.1, ECO:0000313|Proteomes:UP000041254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhu J., Qi W., Song R.;
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777}.
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DR EMBL; CDMY01000238; CEL95783.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G4EIF2; -.
DR STRING; 1169540.A0A0G4EIF2; -.
DR VEuPathDB; CryptoDB:Vbra_5021; -.
DR InParanoid; A0A0G4EIF2; -.
DR OMA; KFWNLKC; -.
DR OrthoDB; 651667at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000041254; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00477; FTHFS; 1.
DR Gene3D; 1.10.8.770; -; 1.
DR Gene3D; 3.10.410.10; Formyltetrahydrofolate synthetase, domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01543; FTHFS; 1.
DR InterPro; IPR000559; Formate_THF_ligase.
DR InterPro; IPR020628; Formate_THF_ligase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01268; FTHFS; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00721; FTHFS_1; 1.
DR PROSITE; PS00722; FTHFS_2; 1.
PE 3: Inferred from homology;
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Reference proteome {ECO:0000313|Proteomes:UP000041254}.
SQ SEQUENCE 632 AA; 67313 MW; 504967121773A745 CRC64;
MAYRDDDLVC AWPVPSDLDI AQSIAPIPMQ ELSAKMGLAQ EEIHYYGRYK AKVDLCVLDR
LKDAPNGKYV VVTGVTPTPL GEGKTTTTVG LSQAFGKHLG CPVFTCVRQP SMGPTFGMKG
GAAGGGYSQI IPMEEFNLHL TGDLHAVAIA NNLLAAAIDT RMFHESTQKD EALFDRLVPR
DSAGGKRRFA PVMKKRLAKL GIDPEIDGDS LTAEQKGAFA RLDIDPDTII TRRVVDVNDR
ALRGITIGKG ENEKAPRETG FDIAVASEAM AILALAQDLP DLRDRLGRAV VASSKNGDAI
TADDLGVGGA MTVLMKDALM PTLLQTLEGT PVFVHAGPFA NIAHGNSSIV ADKVALKMVG
PEGFVITEAG FGADVGFEKF CDIKCRSSGL HPDCAVIVAT VRALKLHGGG PPVIAGKPKA
PCYTSEEVDL VEKGCCNLQV HVRNCRKYGL PVVVCVNRHP TDTAREIDIV CQKAVEAGAN
KAVCGEHWSS GGKGAVALAE AVKEACSLPE KAFSFLYPLD ISIKEKISAI CVNIYGAKDV
EYSDVANAKV ERFEKQGFSG MPICMAKTQY SLSHDADLKG APTGFTVLVK DVGAGFIYPL
LGPIMTMPGL PTRPAFYDVD IDFSTGKITG LF
//
