ID   A0A0G4EM73_VITBC        Unreviewed;       437 AA.
AC   A0A0G4EM73;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   28-JUN-2023, entry version 32.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit M {ECO:0000256|HAMAP-Rule:MF_03012};
DE            Short=eIF3m {ECO:0000256|HAMAP-Rule:MF_03012};
GN   ORFNames=Vbra_7814 {ECO:0000313|EMBL:CEL98037.1};
OS   Vitrella brassicaformis (strain CCMP3155).
OC   Eukaryota; Sar; Alveolata; Colpodellida; Vitrellaceae; Vitrella.
OX   NCBI_TaxID=1169540 {ECO:0000313|EMBL:CEL98037.1, ECO:0000313|Proteomes:UP000041254};
RN   [1] {ECO:0000313|EMBL:CEL98037.1, ECO:0000313|Proteomes:UP000041254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhu J., Qi W., Song R.;
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000256|HAMAP-Rule:MF_03012}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000256|HAMAP-Rule:MF_03012}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03012}.
CC   -!- SIMILARITY: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
CC       {ECO:0000256|ARBA:ARBA00008482}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit M family. {ECO:0000256|HAMAP-
CC       Rule:MF_03012}.
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DR   EMBL; CDMY01000261; CEL98037.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G4EM73; -.
DR   STRING; 1169540.A0A0G4EM73; -.
DR   VEuPathDB; CryptoDB:Vbra_7814; -.
DR   InParanoid; A0A0G4EM73; -.
DR   OMA; AQRCILA; -.
DR   OrthoDB; 211837at2759; -.
DR   PhylomeDB; A0A0G4EM73; -.
DR   Proteomes; UP000041254; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03012; eIF3m; 1.
DR   InterPro; IPR045237; COPS7/eIF3m.
DR   InterPro; IPR027528; eIF3m.
DR   InterPro; IPR040750; eIF3m_C_helix.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR15350; COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17; 1.
DR   PANTHER; PTHR15350:SF2; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M; 1.
DR   Pfam; PF18005; eIF3m_C_helix; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_03012};
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW   Rule:MF_03012};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW   Rule:MF_03012}; Reference proteome {ECO:0000313|Proteomes:UP000041254}.
FT   DOMAIN          207..374
FT                   /note="PCI"
FT                   /evidence="ECO:0000259|PROSITE:PS50250"
SQ   SEQUENCE   437 AA;  49908 MW;  5F7F0A5C13852453 CRC64;
     MTTFLPLNED TDGQKAAVGI ADWLLDNCIK PRLPTEEANT FWTEFSETFK QQDFIQIFHL
     LLKYEPQVFQ TITLAETPEA KLKALKECEG FFTVLMSILL RFEDEDEIMR SAETLGKALS
     RDTDTPDLRL RLLMALYNMF QPAFPVRYPV FVSIVQYAAK VERFEVLVPY LSCLEAWMAD
     WNLKPKQRRA LHQAIGKNLK KANRGNVAFK HIKEFLKGYQ GESESELDKE EVISAAMELC
     EDAIRLPSLM YYDSILSLDA VRHLQHTPYK KLVELVEILT EGGLPELKAF YEANGKLFQE
     HDISFDACAR KIRLLSLTSL ALGKSELSLD LIGETLDVPA GEVESWVVTA IGQGLLDARI
     DQMRRVVLIK SAMQRQFGRP QWETLKQRLV AWQKNVEQLM SVWESTRQKR GEAIGEMTSG
     MLANGHGGRD SSSDFRR
//