ID A0A0G4ERN0_VITBC Unreviewed; 617 AA.
AC A0A0G4ERN0;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN ORFNames=Vbra_12725 {ECO:0000313|EMBL:CEL99948.1};
OS Vitrella brassicaformis (strain CCMP3155).
OC Eukaryota; Sar; Alveolata; Colpodellida; Vitrellaceae; Vitrella.
OX NCBI_TaxID=1169540 {ECO:0000313|EMBL:CEL99948.1, ECO:0000313|Proteomes:UP000041254};
RN [1] {ECO:0000313|EMBL:CEL99948.1, ECO:0000313|Proteomes:UP000041254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhu J., Qi W., Song R.;
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004888}.
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}.
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DR EMBL; CDMY01000292; CEL99948.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G4ERN0; -.
DR STRING; 1169540.A0A0G4ERN0; -.
DR VEuPathDB; CryptoDB:Vbra_12725; -.
DR InParanoid; A0A0G4ERN0; -.
DR OMA; ADCVQQF; -.
DR OrthoDB; 5481886at2759; -.
DR PhylomeDB; A0A0G4ERN0; -.
DR UniPathway; UPA00109; UER00180.
DR Proteomes; UP000041254; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008865; F:fructokinase activity; IEA:RHEA.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.40.367.20; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF16; HEXOKINASE TYPE 1-RELATED; 1.
DR Pfam; PF00349; Hexokinase_1; 1.
DR Pfam; PF03727; Hexokinase_2; 1.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS51748; HEXOKINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007};
KW Glycolysis {ECO:0000256|RuleBase:RU362007};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362007};
KW Reference proteome {ECO:0000313|Proteomes:UP000041254};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}.
FT DOMAIN 146..376
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 386..612
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
SQ SEQUENCE 617 AA; 67702 MW; F7D158A0259E2F12 CRC64;
MKTNRLSSFV LHPCGPPRVT CIPSKHRSAM PFVTSWTRGV GAALLSHSPS TSFSRGEDGR
PSPWHRWRFP FSNRRGAAHC QGGGWQGGGI DLSIPAGHAT YNLYMPVTIY HTGGPGDLPP
YLQAVASSGG LSQGVPLEPS AEIKIKPIRS LLSVGKPQMI MMISEFMEEM NKGLALHAAD
PSAHWDEKKC CFKMLETHID HIPTGSEKGV YYAVDVGGTN FRVVRIELLG DGKIGKTSRI
KRDLKQLPPA PEKPKGLLDA SVKQSEFFGY LADQVIQVGK HEGDIAGEGL EGEASPVLGF
GFTFSFPTQQ DQKNHAILSH WTKEWDTGRD YTGTDECIEG RDVGQMFDDA FAKKGGHAKV
HGVINDTVGT LLSCSYENPH LPPVYMGLIL GTGSNGCYYE PKYKQYSYNG KLINIEFGNF
NRSLPETDID KQVDADLSNK ADVGRQRFEK MVSGKYLGEI SRRFVCSIMA DKLKGTKAEL
IDSLKSEHAS KIVQDESQNL EITCLTLFEQ WGVTFSLNEL RAIQEICRLV FDRSASLAAM
SIVAVALKAD RIGRNAEGMT VAIDGSLYTQ NPWYQHRLKQ HIVDIVGRED AQKVHLQIAD
DGSGKGAAVM VAADQQA
//
