ID A0A0G4FXE6_VITBC Unreviewed; 733 AA.
AC A0A0G4FXE6;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=Vbra_21764 {ECO:0000313|EMBL:CEM19672.1};
OS Vitrella brassicaformis (strain CCMP3155).
OC Eukaryota; Sar; Alveolata; Colpodellida; Vitrellaceae; Vitrella.
OX NCBI_TaxID=1169540 {ECO:0000313|EMBL:CEM19672.1, ECO:0000313|Proteomes:UP000041254};
RN [1] {ECO:0000313|EMBL:CEM19672.1, ECO:0000313|Proteomes:UP000041254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhu J., Qi W., Song R.;
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. NEK Ser/Thr
CC protein kinase family. NIMA subfamily. {ECO:0000256|ARBA:ARBA00010886}.
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DR EMBL; CDMY01000518; CEM19672.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G4FXE6; -.
DR STRING; 1169540.A0A0G4FXE6; -.
DR VEuPathDB; CryptoDB:Vbra_21764; -.
DR InParanoid; A0A0G4FXE6; -.
DR OrthoDB; 198307at2759; -.
DR Proteomes; UP000041254; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR019530; Intra-flagellar_transport_57.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR44899; CAMK FAMILY PROTEIN KINASE; 1.
DR PANTHER; PTHR44899:SF3; SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF10498; IFT57; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000041254};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..247
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 255..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 605..646
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 264..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 733 AA; 81319 MW; AEEBF973683147DE CRC64;
MARSPSDDER VVALKKVNAF DEMDQKSKEK CLKEVRLLQS LDHPHIVAYL DSFISAGELY
IIVEWAERGD LKRLIKRTAQ DESAFSESEC VEYGRQLASA IAHMHDKRIL HRDLKPANIF
LAQDGRLKVG DLGLGRIMSS QTFEAHSKVG TPLYMSPEVL GGGGYDFKSD VWALGCILYE
LATLKSPFRG EKQMSLYELY MKISKGDYPP LPYSLSEELR SLIVSMLSTA PAHRPSIREV
LSRLEALCKP PAACVIPRTP PPQPEAERPD EGEREEVLER PTTSRAHRAP PLLVMDDIVD
KLMMLDYQRL FAAPRGYPPL HRAFFAQAPP PGQRVDAFQY HYDLLMWLFS LQSDPTASDR
PPTRTGGQRP SSLSPPVSRE EALGRLRDEL SRRGISMASV GSLSQLSSGY GEQACLVLNE
VINQELLRRD FHFSPPSLRA HEAITFPEGP GEATDEEGVE HDDMLIVACP LSRSEDTDAA
DQHDAAVIDE SLLPLSIRRP PPSHCGADVA EDHHDMIETS IEPSAWRQEC DRVGDRLNVV
LPAGARDGAF GVGGSVEVFM RYAAAAIDAS GEAVRERLEG VSGSLGEELE TIRLTEGQMN
DDGALRQLAE EATTLRASLA TAESDLEAAR ERVTHLTETL EALSCRHDDL QDAQEQQAES
HSSDEAIPRM RDMTNRLRDD IRALDIRIGV ASADLLRHAV ERRRGVASET RADEGGEEGD
LGCLDERHVR DFM
//
