ID   A0A0G4G9V1_VITBC        Unreviewed;      1418 AA.
AC   A0A0G4G9V1;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=6-pyruvoyltetrahydropterin synthase {ECO:0000256|ARBA:ARBA00013100};
DE            EC=4.2.3.12 {ECO:0000256|ARBA:ARBA00013100};
GN   ORFNames=Vbra_9834 {ECO:0000313|EMBL:CEM25797.1};
OS   Vitrella brassicaformis (strain CCMP3155).
OC   Eukaryota; Sar; Alveolata; Colpodellida; Vitrellaceae; Vitrella.
OX   NCBI_TaxID=1169540 {ECO:0000313|EMBL:CEM25797.1, ECO:0000313|Proteomes:UP000041254};
RN   [1] {ECO:0000313|EMBL:CEM25797.1, ECO:0000313|Proteomes:UP000041254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhu J., Qi W., Song R.;
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- PATHWAY: Cofactor biosynthesis; tetrahydrobiopterin biosynthesis;
CC       tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.
CC       {ECO:0000256|ARBA:ARBA00005126}.
CC   -!- SIMILARITY: Belongs to the PTPS family.
CC       {ECO:0000256|ARBA:ARBA00009164}.
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DR   EMBL; CDMY01000603; CEM25797.1; -; Genomic_DNA.
DR   STRING; 1169540.A0A0G4G9V1; -.
DR   VEuPathDB; CryptoDB:Vbra_9834; -.
DR   InParanoid; A0A0G4G9V1; -.
DR   OrthoDB; 35834at2759; -.
DR   PhylomeDB; A0A0G4G9V1; -.
DR   UniPathway; UPA00849; UER00819.
DR   Proteomes; UP000041254; Unassembled WGS sequence.
DR   GO; GO:0003874; F:6-pyruvoyltetrahydropterin synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd08255; 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_like; 1.
DR   Gene3D; 3.30.479.10; 6-pyruvoyl tetrahydropterin synthase/QueD; 2.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 3.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR007115; 6-PTP_synth/QueD.
DR   InterPro; IPR038418; 6-PTP_synth/QueD_sf.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43350:SF22; D-GULOSIDE 3-DEHYDROGENASE; 1.
DR   PANTHER; PTHR43350; NAD-DEPENDENT ALCOHOL DEHYDROGENASE; 1.
DR   Pfam; PF00107; ADH_zinc_N; 2.
DR   Pfam; PF01242; PTPS; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   SUPFAM; SSF55620; Tetrahydrobiopterin biosynthesis enzymes-like; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000041254};
KW   Tetrahydrobiopterin biosynthesis {ECO:0000256|ARBA:ARBA00023007}.
FT   DOMAIN          1097..1200
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
FT   DOMAIN          1240..1338
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
FT   REGION          470..494
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..485
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1418 AA;  156285 MW;  E363222173DCBF2C CRC64;
     MTALVRPRCV ASRGLSRAFS TYTLTIRRPL HGDALQGDFY GFLHGAVNLL TASVTSSTLR
     ADGHLVKSSA LKEACRIKEW CKHATELSGN LPAFRKYLLS KVEAGDPVDD MRLGLRDSYS
     FYGFAHSPAY PWDEERDPAR VCETAMLAHS FRGKSFGPAQ RMHGATILVE AWLYHHLDER
     DLAKALIDAL KPFENQNLDT SPWTQGANTT IEWIAFKLWE DMAVNFRPER LEDGAAETPP
     SPPKNKKRLK IIVHESDIAS CSFEGPTDPA PPPAHLGHFS VTVRDRCMIA RRLDGAEDLH
     GATLLVDMTF KGPRLREPEN FLVDIGMCQA LLGEAVGGLA YRNLEEIEAM KGENWTLEML
     SRYLWERVRS AYLSLPPADR QSPPEPLSSL TITVSDGPDP LATSASFEGP LDTPQSAAAL
     LPPIAFNVDL IASAEVKAIV RRCLDSKERG GWAAIEKELT AYLLNKETAR VSGQTDDRDG
     RKESTTPTGW QHMASEGATP RWIRDLLRWT SPGHMLFYSR CLPSSMVSRI VMPERGGVPM
     VGGEAFIGEG GRGPQYERLR DAWKELGGGE KELVVIDDPE VIDSSVQAIS HAIKGVSLAP
     LPTSPSTLEQ SLASLIKCAP PQSTFQFDPL AYLSAKKAID CHAFNEDTWE AFVARFREKE
     PRDCGVRVLD VGAGRLGMLV RVLGLWEGHQ WKGRGDALVY VAIDTSRAVM QANRESATEL
     MGFEEVDESF GFHPRERVYR KADRGGGGIY LVLVEGDLLD TADGQHGFDV VLGCSFADLM
     DQDVLINHLT RIAPGALLYM PITYAGRTTF DPPFFGGGAL PTDRQVVSLY HEHLRREGQS
     TDPSKLLRAI ESRKGQIMMQ GASEWSVPCA DHQYMWQCLM SFLAMGALRS CQLLPHWDLP
     AWVKHHTDKH STLKVKNVDI LGTLPADMSV YVAAAFPSRQ VVFSGPSRVE IRDRPQAIKV
     PPGHVEVESA YSLISSGTEL KVYQGDFIDG EPLDTSIEGM TATPLRYPLT YGYSLAGKCV
     RCGSGVDRLS WLGQKVFAFH SHEERAIVPL SSCTRLPADV PVDDAIFLPA METALSLLQD
     ANPVPGEQVA VFGQGLIGLL VTYLLARQRW HVTAIDPSEQ RRRLAREAGA SAVLAPSSAH
     DPPSPFDCVI EVSGRPTALD AALRVTRNNG RVVVGSWYSK GFAGFAELDL GSLRLHRSHI
     QVKFSQVSEI PPSLRGRWTK DRRLDEALRE QVAVFGQGLI GLLVTYLLAR QRWHVTAIDP
     SEQRRRLARE AGASAVLAPS SAHDPPSPFD CVIEVSGRPT ALDAALRVTR NNGRVVVGSW
     YSKGFAGFAE LDLGSLRLHR SHIQIKFSQV SEIPPSLRGR WTKDRRLDEA LRVLAELSPS
     TCSFLPVQTF PASRAKEAYD QLAKGTAVLA RLHWKGTE
//