ID A0A0G4H277_VITBC Unreviewed; 1248 AA.
AC A0A0G4H277;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=HECT domain-containing protein {ECO:0000259|PROSITE:PS50237};
GN ORFNames=Vbra_19374 {ECO:0000313|EMBL:CEM37763.1};
OS Vitrella brassicaformis (strain CCMP3155).
OC Eukaryota; Sar; Alveolata; Colpodellida; Vitrellaceae; Vitrella.
OX NCBI_TaxID=1169540 {ECO:0000313|EMBL:CEM37763.1, ECO:0000313|Proteomes:UP000041254};
RN [1] {ECO:0000313|EMBL:CEM37763.1, ECO:0000313|Proteomes:UP000041254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhu J., Qi W., Song R.;
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CDMY01000954; CEM37763.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G4H277; -.
DR STRING; 1169540.A0A0G4H277; -.
DR VEuPathDB; CryptoDB:Vbra_19374; -.
DR InParanoid; A0A0G4H277; -.
DR OMA; ERIWHAV; -.
DR OrthoDB; 276649at2759; -.
DR PhylomeDB; A0A0G4H277; -.
DR Proteomes; UP000041254; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR PANTHER; PTHR45700:SF8; HECT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 4.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50012; RCC1_3; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000041254};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 208..261
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 262..313
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 314..365
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 366..419
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 420..476
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 917..1248
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1216
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1248 AA; 139994 MW; B7544969A22D5636 CRC64;
MEPDGTSLAR TVSHHPTYPP PRPPNQDTVS RAAPQAPQNE RSQSNISQIS EALRDENFFN
FTDGSFVWTF GDNYCGQVLN EGTEPVRQPV LLTKLRKQRI LKVACGFETT WIIGDNGDVW
AGGSNDSGQV TGLMDDEYDM AEQDEAMQPT EGPPTGENDN KRPRSAPTTS RGAPDSINHA
KRLELRENQK VRTLQSGRDH TVAVLDSGVA LSFGSNEFGQ LGHGTPPSIQ RCKAGVMRVS
PGSKVQSVAC GQGFTIVLMA TGQLLSCGDG GQGCLGHGSL ESRSALGPIP TLMGMPMNQV
ACGVNHCMAL SITGEAYGWG KCRDGQLGLG DTVSDDKKLV PCRVPIERAK YVACGGAHSA
IIARKGRLLM TGSNKYGQLG APTGLVEDRR EFAPVEALAE MKIRIAQLGL RHTLCITYMG
TLLAFGCNQH GQLGIGSDEA LVCQPTEITF KDVPHQRQFF FSLSSGQDHA IAVATSDPPL
RVKKGSGTRE IDEWLAKERS MIRTFSDYRN EKGLRLSDFP RYVSSDLSPM RKALRAFASS
VESGTGVTAQ ELREVIDAHS LDIIPLKHQL HVILADVHTM NASFLVGVKR KLFDAEGLES
AYRQLFALSQ IADIIPELIS HFEKCLMSVA TYEKELRTSD QLRFIMESNP RERERERQND
RAIQKHAPCV MCVCARGCLQ IILQCPLFSV PTSLTVPLMA KLAEVTFKLS QRGKETLVRM
AKEDTTPEVF GGRLVAHVVA YLNHQIEHHT PHYRQLERIW HAVHLLQLLY LANWECAKER
KVDENGASRD FRIPLQRFHL DGITRFIDVV SECKMFYELF RDPKHQDQEG HRLAWRPQQV
LTVSQLNHSN TFFLAHHNLC PLPYKRKALR VEAGRYQEEY MVRSLIQMEI PYFVVTVQRD
NLLNTALARI MSVAQGSPHE FIKPLKIKFE NEEGVDEGGV LREFYRLITQ EVLNPDFGMF
VYNEQIRTIW FNRLSLDDNL SMFAFVGILL GLALYNNVLL ELPFPLALYK LLQHEPIGLE
DLADTFPDQA HSFQQILDHQ PGEEFDAAFG ELPFEVTFDY FGETKTVELT EGGSEKTLTY
DNRQDYVELY TRYLLVDSVK EPIERFCKGF RGAAHSELIT VVTPSELQLL MCGTPQLDFE
ELRKGARYDG GYTPDHPYIN TFWQILMSFD QEHKRKFLIF CTGSDRAPLG GLEDLRLLIQ
RNGTEPTVRL PTAYTCYNAL LLPEYADGDK LQKLLVQAIE QAEGFGLR
//
