ID A0A0G4H5X8_VITBC Unreviewed; 575 AA.
AC A0A0G4H5X8;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=tRNA (guanine(26)-N(2))-dimethyltransferase {ECO:0000256|ARBA:ARBA00039099, ECO:0000256|PROSITE-ProRule:PRU00958};
DE EC=2.1.1.216 {ECO:0000256|ARBA:ARBA00039099, ECO:0000256|PROSITE-ProRule:PRU00958};
GN ORFNames=Vbra_6647 {ECO:0000313|EMBL:CEM39225.1};
OS Vitrella brassicaformis (strain CCMP3155).
OC Eukaryota; Sar; Alveolata; Colpodellida; Vitrellaceae; Vitrella.
OX NCBI_TaxID=1169540 {ECO:0000313|EMBL:CEM39225.1, ECO:0000313|Proteomes:UP000041254};
RN [1] {ECO:0000313|EMBL:CEM39225.1, ECO:0000313|Proteomes:UP000041254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhu J., Qi W., Song R.;
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) +
CC N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:43140, Rhea:RHEA-COMP:10359, Rhea:RHEA-COMP:10360,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74269, ChEBI:CHEBI:74513; EC=2.1.1.216;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU00958};
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Trm1 family. {ECO:0000256|PROSITE-ProRule:PRU00958}.
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DR EMBL; CDMY01001028; CEM39225.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G4H5X8; -.
DR STRING; 1169540.A0A0G4H5X8; -.
DR VEuPathDB; CryptoDB:Vbra_6647; -.
DR InParanoid; A0A0G4H5X8; -.
DR OrthoDB; 942596at2759; -.
DR PhylomeDB; A0A0G4H5X8; -.
DR Proteomes; UP000041254; Unassembled WGS sequence.
DR GO; GO:0160102; F:tRNA (guanine(10)-N2)-methyltransferase activity; IEA:InterPro.
DR GO; GO:0160104; F:tRNA (guanine(26)-N2)-dimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006400; P:tRNA modification; IEA:UniProt.
DR Gene3D; 3.30.56.70; N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002905; Trm1.
DR InterPro; IPR042296; tRNA_met_Trm1_C.
DR PANTHER; PTHR10631; N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10631:SF3; TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE; 1.
DR Pfam; PF02005; TRM; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51626; SAM_MT_TRM1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU00958}; Reference proteome {ECO:0000313|Proteomes:UP000041254};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00958};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU00958};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00958}; tRNA processing {ECO:0000256|PROSITE-ProRule:PRU00958};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|PROSITE-
KW ProRule:PRU00958}.
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 575 AA; 61681 MW; 1D432F2939490690 CRC64;
MTDLEEPAAS QDDPVGDEPS TYREGRVLIH APSSKSGSPA AFMNPAMSFN RDLTVLVLHS
FFSALNGTDD SSTGEDSSEG SAAGVPVRRW QGAPALLSSS NVTVLEPYAG TGLRSLRFAA
EVPGIHHAVA NDLCGSAVTS IRANMALNKE STAGRMSVTR SDAADSLWQW RRGERGGKGA
RVGCIDLDPF GSAAEVFPLA AESVCRDGLL CVTCTDIQAL CGGGGGSKST ACWARYGGMP
MATKPRKEGA IRLVLNALNR AAALHGRSIL PLLSLSVDYY IRVYVQILEG GGGLVDSAIN
TGMVATCPSC RQFDVMPAAS CRWGPKQWVL TPTTICGKER EDRCKCGAAK GDAARTLAGP
MWIGPLHDKT FVRHLLSTLR DLKEQDQSAA NGMPVLTNRA ELEGLLTVIN EECSLDEPCP
FFYHLEDIAY NMAHFQPPLR EMRAGLSRLG WSVSQSHTDP STLKTSAPFS VLLDVALAWA
VSKGPEVLRQ IAQRAKSKWL RKEADEMLSN IELVGSRDLG ALSVCSERPD GSSDFVNVSR
GSSRAEFAVK SKHTHVRRWL QRAKRVGPGA RPAKG
//