ID A0A0G4J322_PLABS Unreviewed; 759 AA.
AC A0A0G4J322;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=aspartate kinase {ECO:0000256|ARBA:ARBA00013059};
DE EC=2.7.2.4 {ECO:0000256|ARBA:ARBA00013059};
GN ORFNames=PBRA_008691 {ECO:0000313|EMBL:CEP01749.1}, PLBR_LOCUS8685
GN {ECO:0000313|EMBL:SPR01470.1};
OS Plasmodiophora brassicae (Clubroot disease agent).
OG Mitochondrion {ECO:0000313|EMBL:SPR01470.1}.
OC Eukaryota; Sar; Rhizaria; Endomyxa; Phytomyxea; Plasmodiophorida;
OC Plasmodiophoridae; Plasmodiophora.
OX NCBI_TaxID=37360 {ECO:0000313|EMBL:CEP01749.1, ECO:0000313|Proteomes:UP000039324};
RN [1] {ECO:0000313|EMBL:CEP01749.1, ECO:0000313|Proteomes:UP000039324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E3 {ECO:0000313|EMBL:CEP01749.1};
RA Chooi Y.-H.;
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SPR01470.1, ECO:0000313|Proteomes:UP000290189}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Fogelqvist J.;
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-aspartate = 4-phospho-L-aspartate + ADP;
CC Xref=Rhea:RHEA:23776, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57535, ChEBI:CHEBI:456216; EC=2.7.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000709};
CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC {ECO:0000256|RuleBase:RU004249}.
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC pathway; L-homoserine from L-aspartate: step 1/3.
CC {ECO:0000256|ARBA:ARBA00004986, ECO:0000256|RuleBase:RU004249}.
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC from L-aspartate: step 1/5. {ECO:0000256|ARBA:ARBA00005139,
CC ECO:0000256|RuleBase:RU004249}.
CC -!- SIMILARITY: Belongs to the aspartokinase family.
CC {ECO:0000256|ARBA:ARBA00010122}.
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DR EMBL; CDSF01000117; CEP01749.1; -; Genomic_DNA.
DR EMBL; OVEO01000017; SPR01470.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G4J322; -.
DR STRING; 37360.A0A0G4J322; -.
DR EnsemblProtists; CEP01749; CEP01749; PBRA_008691.
DR OrthoDB; 2608453at2759; -.
DR UniPathway; UPA00034; UER00015.
DR UniPathway; UPA00050; UER00461.
DR UniPathway; UPA00051; UER00462.
DR Proteomes; UP000039324; Unassembled WGS sequence.
DR Proteomes; UP000290189; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0004072; F:aspartate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04921; ACT_AKi-HSDH-ThrA-like_1; 1.
DR Gene3D; 3.40.1160.10; Acetylglutamate kinase-like; 1.
DR Gene3D; 3.30.2130.10; VC0802-like; 1.
DR InterPro; IPR036393; AceGlu_kinase-like_sf.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR001341; Asp_kinase.
DR InterPro; IPR018042; Aspartate_kinase_CS.
DR InterPro; IPR027795; CASTOR_ACT_dom.
DR NCBIfam; TIGR00657; asp_kinases; 1.
DR PANTHER; PTHR21499; ASPARTATE KINASE; 1.
DR PANTHER; PTHR21499:SF3; ASPARTOKINASE; 1.
DR Pfam; PF00696; AA_kinase; 1.
DR Pfam; PF13840; ACT_7; 1.
DR SUPFAM; SSF55021; ACT-like; 2.
DR SUPFAM; SSF53633; Carbamate kinase-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS00324; ASPARTOKINASE; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|RuleBase:RU004249};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Mitochondrion {ECO:0000313|EMBL:SPR01470.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000039324};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 421..498
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 759 AA; 81041 MW; CE3B44AD57C338E9 CRC64;
MAWVVHKFGG TSVADAGCYR RAVSLLGDDI GAGHGVVVVV SAQGRARDAH GAMTHDKVTS
LLIECASRAA RRDSSYADVL RAVVDRHVAA AHDLIDDDTE RDAFLRRLNA DATDLHHILK
SAWLGRRASS DGSPCPWWTG YGELWSARLF AIHLRESLPD DIAVEFIDAR SLVVVGEGGY
PDMAETSTRW QAWRIKHGDV RVAVLTGFIC AAHDGTPSTL GRDGSDYSAS IAAAMIPASS
LTIWSDVDGV FSADPTMVPG AVVRNEMTYN EAMELAYFGA KVLHPKTMSP LLNLDIPIRI
RNTFRPDIPG SRIVASRPAG SADIVIQGFS TIMDLMLINV EGTGMIGVSG IAHRLFGAIH
RAGSSVILIT QAGSEHSICL ALPYAQASAA VDAIYAEFRV ELEAGDIQTV DCLGPCACLA
AVGDGMRHAT GIAGQVLTAL GRANINIRAI AQGASERNIS VVIDQVDASA ALNAVHGQFV
SNDANRIIAL ATYNCCDRVQ RLVDSIPDLC VSLWNGEVPP PSSIVIDCSG DDTVDYVPAL
KSNCHVITCN VFAAARASPS SNLWTHGITD ASVPFQATVA AIHDSGDTVE RVVLALPDSV
SNTAASDNAD ASVGERDCKE RLPSRSAHRG RCLLVVLSNA IGMPITLDDI VSDSETELDA
ADEECDSARL QRTEGKSEAH AMHVWELDLI TRTARSDLLQ TKHMHADSRR LSVEIYTRRR
GGSDPIALSG PASVNDDVII GLMQSQLTRV LRQTKCPTN
//
