ID   A0A0G4LXT6_9PEZI        Unreviewed;       951 AA.
AC   A0A0G4LXT6;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=laccase {ECO:0000256|ARBA:ARBA00012297};
DE            EC=1.10.3.2 {ECO:0000256|ARBA:ARBA00012297};
GN   ORFNames=BN1708_000644 {ECO:0000313|EMBL:CRK26836.1};
OS   Verticillium longisporum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=100787 {ECO:0000313|EMBL:CRK26836.1, ECO:0000313|Proteomes:UP000044602};
RN   [1] {ECO:0000313|EMBL:CRK26836.1, ECO:0000313|Proteomes:UP000044602}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VL1 {ECO:0000313|EMBL:CRK26836.1};
RA   Wang D.B., Wang M.;
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-ureidoglycolate = glyoxylate + urea; Xref=Rhea:RHEA:11304,
CC         ChEBI:CHEBI:16199, ChEBI:CHEBI:36655, ChEBI:CHEBI:57296; EC=4.3.2.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00001281};
CC   -!- COFACTOR:
CC       Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC         Evidence={ECO:0000256|ARBA:ARBA00001935};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the multicopper oxidase family.
CC       {ECO:0000256|ARBA:ARBA00010609}.
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DR   EMBL; CVQH01020306; CRK26836.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G4LXT6; -.
DR   STRING; 100787.A0A0G4LXT6; -.
DR   OrthoDB; 449862at2759; -.
DR   Proteomes; UP000044602; Unassembled WGS sequence.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0004848; F:ureidoglycolate hydrolase activity; IEA:InterPro.
DR   GO; GO:0050385; F:ureidoglycolate lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000256; P:allantoin catabolic process; IEA:InterPro.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd20298; cupin_UAH; 1.
DR   CDD; cd13854; CuRO_1_MaLCC_like; 1.
DR   CDD; cd13880; CuRO_2_MaLCC_like; 1.
DR   CDD; cd13901; CuRO_3_MaLCC_like; 1.
DR   Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 3.
DR   Gene3D; 2.60.120.480; Ureidoglycolate hydrolase; 1.
DR   InterPro; IPR011707; Cu-oxidase-like_N.
DR   InterPro; IPR001117; Cu-oxidase_2nd.
DR   InterPro; IPR011706; Cu-oxidase_C.
DR   InterPro; IPR045087; Cu-oxidase_fam.
DR   InterPro; IPR002355; Cu_oxidase_Cu_BS.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   InterPro; IPR047233; UAH_cupin.
DR   InterPro; IPR007247; Ureidogly_lyase.
DR   InterPro; IPR024060; Ureidoglycolate_lyase_dom_sf.
DR   PANTHER; PTHR11709:SF87; LACCASE; 1.
DR   PANTHER; PTHR11709; MULTI-COPPER OXIDASE; 1.
DR   Pfam; PF00394; Cu-oxidase; 1.
DR   Pfam; PF07731; Cu-oxidase_2; 1.
DR   Pfam; PF07732; Cu-oxidase_3; 1.
DR   Pfam; PF04115; Ureidogly_lyase; 1.
DR   SUPFAM; SSF49503; Cupredoxins; 3.
DR   SUPFAM; SSF51182; RmlC-like cupins; 1.
DR   PROSITE; PS00080; MULTICOPPER_OXIDASE2; 1.
PE   3: Inferred from homology;
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Purine metabolism {ECO:0000256|ARBA:ARBA00022631};
KW   Reference proteome {ECO:0000313|Proteomes:UP000044602};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..951
FT                   /note="laccase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002566938"
FT   DOMAIN          82..192
FT                   /note="Plastocyanin-like"
FT                   /evidence="ECO:0000259|Pfam:PF07732"
FT   DOMAIN          202..350
FT                   /note="Plastocyanin-like"
FT                   /evidence="ECO:0000259|Pfam:PF00394"
FT   DOMAIN          431..546
FT                   /note="Plastocyanin-like"
FT                   /evidence="ECO:0000259|Pfam:PF07731"
FT   REGION          839..864
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   951 AA;  102934 MW;  0035A28B0750C6D1 CRC64;
     MSLRFICFGL VACWVAGLTS AMPATDPPLR PFGKYGCGQH SPKNRACWRD NFDIFTDTSS
     KIPDTGKTRT YDLTITNVSS FSSADGVSKP AMLINGQFPG PTIVADWGDW VKINVHNQLQ
     HNGTSIHWHG IWQKNTNDQD GANGVTECPI PPGASKTYLF RMHQYGTAWY HSHFSSQYGN
     GVVGTIQING PASANYDVDL GPFSITDWYY ETADRLERRA ELVSNGPPPE SDNVLFNGTH
     VNAQGGGQYS RTTLQPGKKH RLRLINTSSD NAFTVSMVGH TFTVIETDLV PVVPVKKDTL
     FLTVGQRYDV IIEANQKVEN YWFNATLASS RFCGTTRIKQ PAAIFSYAGA SKTKQPTNPG
     TPVNAVCSDT VGFSPVVTKG APKEEFLKSQ GYLDVNLKTP VIDDVAVFRW EVNGSSINVE
     WDRPILEYIR EGDFDWPREA NVIDIAQKNV WTFWVLQNLG PAPHPMHLHG HDFLVLGAGD
     GQFDRVAGVN SLNFDNPIRR DVAELPGGGH LVIAFQTDNP GAHLLHCHIA WHVSRGLSVM
     FLERKGDIPT TVNLDNLEPN CKKWRAYEPT AVWPQSDSEE RCFPVLVGLG LHVRPPHFDS
     WGQLQTSKLK LKLKLKLKFE LELPHLTSST PPIHVTYSIA IIIIIINQII ITSPTRPVAQ
     ETFPPYSSSA PTAKAMPPIK LSLNGQNLTI PAVPLTPSAF APFGDVIQNP HPAVAPSPTL
     PPHLALRAVS ANQGSAIKYQ HPSVPANHYA TAPSGTPAQP VLNLFVCAAR PLDHPHPPAP
     PPISTLLPYT PVVHQGPGLF RVRILERHPF TTQTFAPLAG PDRSPAAGYL VIVAPSKAAG
     PEDEGLPNPD PGTAASASGT SGYPGRGVPD LAGLRAFVAT TGQAVTYGAG TWHAPMVALG
     PQGTSVEFVV TQFANGVADE DCQEVVFGAG QDGSVVVQVP ERSGLGGLAK L
//