ID A0A0G9MYZ2_9SPHN Unreviewed; 871 AA.
AC A0A0G9MYZ2;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=AAW00_09780 {ECO:0000313|EMBL:KLE34498.1};
OS Aurantiacibacter luteus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Erythrobacteraceae; Aurantiacibacter.
OX NCBI_TaxID=1581420 {ECO:0000313|EMBL:KLE34498.1, ECO:0000313|Proteomes:UP000053464};
RN [1] {ECO:0000313|EMBL:KLE34498.1, ECO:0000313|Proteomes:UP000053464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KA37 {ECO:0000313|EMBL:KLE34498.1,
RC ECO:0000313|Proteomes:UP000053464};
RA Zhuang L., Liu Y., Shao Z.;
RT "The draft genome sequence of Erythrobacter luteus KA37.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLE34498.1}.
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DR EMBL; LBHB01000002; KLE34498.1; -; Genomic_DNA.
DR RefSeq; WP_047004145.1; NZ_LBHB01000002.1.
DR AlphaFoldDB; A0A0G9MYZ2; -.
DR STRING; 1581420.AAW00_09780; -.
DR PATRIC; fig|1581420.6.peg.2006; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000053464; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000053464}.
FT DOMAIN 699..715
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 625..632
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 871 AA; 92804 MW; 6C2A55893D5B9377 CRC64;
MTAQPTPMMQ QYLGLKAEAG DCLLFYRMGD FFELFFDDAR TAAQVLDIAL TARGEHGGDP
VPMCGVPVHA AEGYLARLIK AGCRVAIAEQ VETPDEARAR AKREGTPSSK ALVRRDIVRF
VTAGTLTEEA LLEPRRANVL AAVCELRGVC GVASVDISTG AMVLEECAPE RLGAALARVG
ASECVAPEDW TEAPLEAVAR PRADFASEGG EARLKSVHGV ATLDGFGQFS RAMLAAAGGL
LAYLDHAGRG TLPLLLPPVA RASGEHMAMD EATRASLEIL ASQQGGRAGS LIAAIDRCVT
GAGARLLAED LAAPLVDRAS IEARLSLVGW LHRDPLLRAD LRSLLRALPD LGRALGRLVA
GRGSPRDLGQ VRDGLIEARR VHDVLKGKAD RPALLDGLLP ALTGHAELTD LLGRALVPAP
PTERQNGGFI AAGYDHALDE LREVSGNARR AIAAMEARYR DETGTPALKI RHNGVLGYFI
EVPSKHADKL MAPESGFTHR QTMANVVRFN SLTLHEEASR IAEAGGHAQA AEDAHFEDLV
ERVAQRREAV AATAAALARL DVAAGQAERA SEGEWCQPEI VDEPALAIEA GRHPVVEAAL
SKGGERFVAN DCALGEHDRL WLVGGPNMGG KSTFLRQNAL IVLLAQAGGF VPAKAARIGL
VDQLFSRVGA SDNLARGRST FMVEMVETAA ILQQAGPRSF VILDEVGRGT STYDGLALAW
AVAEAIHETN RCRCLFATHY HEMARLAESC EALSLHHVRA REWKGDLVLL HEVAEGAADR
SYGLAVAKLA GVPEAVVKRA RSVLDKLEKG RAETGGLAAG LGDLPLFAAA FQAEEEQCDT
LRDLLAEVDV DALSPREALE MLYRLKREAA D
//
