ID A0A0H0YR67_LACCA Unreviewed; 312 AA.
AC A0A0H0YR67;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Tagatose-6-phosphate kinase {ECO:0000256|PIRNR:PIRNR000535};
DE EC=2.7.1.144 {ECO:0000256|PIRNR:PIRNR000535};
GN ORFNames=AAW28_10690 {ECO:0000313|EMBL:KLI75100.1};
OS Lacticaseibacillus casei (Lactobacillus casei).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lacticaseibacillus.
OX NCBI_TaxID=1582 {ECO:0000313|EMBL:KLI75100.1, ECO:0000313|Proteomes:UP000035289};
RN [1] {ECO:0000313|EMBL:KLI75100.1, ECO:0000313|Proteomes:UP000035289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N87 {ECO:0000313|EMBL:KLI75100.1,
RC ECO:0000313|Proteomes:UP000035289};
RA Zotta T., Bassi D., Parente E., Ricciardi A., Ianniello R.G., Reale A.;
RT "Genetic and physiological basis of aerobic metabolism in Lactobacillus
RT rhamnosus and Lactobacillus paracasei: basic and applied aspects.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose
CC 1,6-bisphosphate + H(+); Xref=Rhea:RHEA:12420, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58694, ChEBI:CHEBI:58695,
CC ChEBI:CHEBI:456216; EC=2.7.1.144;
CC Evidence={ECO:0000256|PIRNR:PIRNR000535};
CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC phosphate: step 1/2. {ECO:0000256|PIRNR:PIRNR000535}.
CC -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family. LacC
CC subfamily. {ECO:0000256|PIRNR:PIRNR000535}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLI75100.1}.
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DR EMBL; LCUN01000014; KLI75100.1; -; Genomic_DNA.
DR RefSeq; WP_047107288.1; NZ_LCUN01000014.1.
DR AlphaFoldDB; A0A0H0YR67; -.
DR PATRIC; fig|1582.46.peg.1041; -.
DR OrthoDB; 9801219at2; -.
DR UniPathway; UPA00704; UER00715.
DR Proteomes; UP000035289; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01164; FruK_PfkB_like; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR InterPro; IPR005926; LacC.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR017583; Tagatose/fructose_Pkinase.
DR NCBIfam; TIGR03168; 1-PFK; 1.
DR NCBIfam; TIGR01231; lacC; 1.
DR PANTHER; PTHR46566:SF5; 1-PHOSPHOFRUCTOKINASE; 1.
DR PANTHER; PTHR46566; 1-PHOSPHOFRUCTOKINASE-RELATED; 1.
DR Pfam; PF00294; PfkB; 1.
DR PIRSF; PIRSF000535; 1PFK/6PFK/LacC; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
DR PROSITE; PS00584; PFKB_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000535};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KLI75100.1};
KW Lactose metabolism {ECO:0000256|ARBA:ARBA00022736,
KW ECO:0000256|PIRNR:PIRNR000535};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR000535};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000535}.
FT DOMAIN 12..297
FT /note="Carbohydrate kinase PfkB"
FT /evidence="ECO:0000259|Pfam:PF00294"
SQ SEQUENCE 312 AA; 34004 MW; 3859926DD6B129D8 CRC64;
MILTVTLNPS IDVSYPLEHL KIDTVNRVKN VRKTAGGKGL NVSRVIHMLD HDLTATGFIG
GYFGKWLEHQ LDRDGIAHDF LPIDAETRSS IAMLHDGGKQ TEILEAGPTI TPEDAQKFLD
HFDKLLDQAD LLTISGSMPQ GLPEDYYTQM IAHAGAKNVK VLLDTSGATL KSALEAPVKP
LLIKPNEEEL AGLLNREVDK TDYAALKQDL KDPIFDGVDW IVVSLGSAGA FVKHQDKFYH
AAIPKIQVVN PVGSGDSTLA GLAMGIHDGK SDEDIMKTAM TTGMLNTMEA ETGFVNPAKF
DTYFAKVTIE NY
//
