ID   A0A0H1B7Z1_9EURO        Unreviewed;       941 AA.
AC   A0A0H1B7Z1;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
GN   ORFNames=EMPG_11174 {ECO:0000313|EMBL:KLJ05351.1};
OS   Blastomyces silverae.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=2060906 {ECO:0000313|EMBL:KLJ05351.1, ECO:0000313|Proteomes:UP000053573};
RN   [1] {ECO:0000313|Proteomes:UP000053573}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 139 {ECO:0000313|Proteomes:UP000053573};
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA   Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease. {ECO:0000256|ARBA:ARBA00025147}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC       subfamily. {ECO:0000256|ARBA:ARBA00038423}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KLJ05351.1}.
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DR   EMBL; LDEV01003695; KLJ05351.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0H1B7Z1; -.
DR   STRING; 2060906.A0A0H1B7Z1; -.
DR   OrthoDB; 276400at2759; -.
DR   Proteomes; UP000053573; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527:SF3; FI21453P1-RELATED; 1.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053573};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT   DOMAIN          32..109
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
FT   REGION          335..401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        377..401
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   941 AA;  104512 MW;  AABD05BD8C87A612 CRC64;
     MAWQPQDQPL RQLAGFLNDS LNGSDSSVRK HAEQMLVQAT TSPDFANYLT YLFSTPQPPP
     HIGFDNDTYN VVRVAASLNL KTKLKVAYGT VTSESLAYIR SAALSVLQDP SPQIRNSAGS
     IIAEIVARGG LLAWPTLLDE LLSLVSNASG SVPILTQEAA MSALSKVCED NKKLLDKDFQ
     GQRPLNIILP RLMQCTSNAS PKIRASALST IHMFLSQRPD ILIGSLDTFL EHVFQLASDP
     NTDVRRTVCQ SFVQLVDIAP DKLVPHIAGL VDYVLMQQHD PEDPELALDA AEFWLAVGEQ
     KKLQEPLVPY LGKIIPVLLR SMIYDEDDAI LLAGEDDDAE TEDKEEDLKP KFAKSKSSRL
     QLASGDGKSN GDAVDKTVAD DDDDLSEGEI EDDLDEFGDD DPEAEWTLRK CSAAALDVFA
     NVYHQPVFEI ILPYLKDNLR HAQWTNREAA VLALGAIADG CMDTVTPHLP ELIPYLISLL
     SDPEPIVRKI TCWCLGRYSE WAAHLDAAKK AQYFEPMMEG ILHRMLDNNK KVQEAAASAF
     TSLEMKSDAN LLPYCQPILR QFVLCFEKYK DRNMYVLYDC VQTLAESVMS ELAKPELVEI
     LMPALIRRWN KLSDQSRELF PLLECLGYVA TAYGDAFSSF APPIFARCIK IIYTNIQDYL
     TAVTHNTGEE PDKDFLVTSL DMLGSIIQAI DPQKSSELVT TSQPPFFELL CFCLEDPNWE
     VRISSYALLG DCAINIFPTL EPVLPTVMPI LIKQLDLNLI RDDESENGLR VINNACWAAG
     EIAAASKAGM APFLENLYQA LTAIVSNEEV PDSVNENGAM ALGRLGIGCA QQLAPHLGEF
     AEIFLRSMAK IDFTREKASS FFGFNQVVRA NPKAMESCLS DYFHAIAVFP HKSLNQPHFQ
     DLQQSFQQVL QGYKDLIPDF NSFMASLPPP VSRKLQTAYQ F
//