ID A0A0H1BDA9_9EURO Unreviewed; 706 AA.
AC A0A0H1BDA9;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=EMPG_15151 {ECO:0000313|EMBL:KLJ09429.1};
OS Blastomyces silverae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=2060906 {ECO:0000313|EMBL:KLJ09429.1, ECO:0000313|Proteomes:UP000053573};
RN [1] {ECO:0000313|Proteomes:UP000053573}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 139 {ECO:0000313|Proteomes:UP000053573};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLJ09429.1}.
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DR EMBL; LDEV01002352; KLJ09429.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0H1BDA9; -.
DR STRING; 2060906.A0A0H1BDA9; -.
DR OrthoDB; 5482027at2759; -.
DR Proteomes; UP000053573; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07652; F-BAR_Rgd1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176:SF138; RHO GTPASE ACTIVATOR; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000053573}.
FT DOMAIN 56..329
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 513..703
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..43
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..389
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..437
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..471
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 706 AA; 77604 MW; 1D1838C63E512916 CRC64;
MADSPPPPPP PPPDDGPAPY AFPRTESELP PRPPSPPAKT ASPEPAPAAV NPEEMAQLEK
VLQSDIGVSI LLTRLKQTIA STKDFSSFLR KRSAIEEEHA QGLKKLARSV HDSAQRIDNR
QGTLSASCDE INRIHDRMAD HGLQFALSLQ QMSDDLNELA ANLERGRKHW KLNGLNAEKR
MQDAESMAEK AKAKYNSLAE QYDRARTGDT QHGKFGLKGP KSAAQHEQDL LRKVQNSDSE
YASKVQAAQG MKSDLISSQR PQAVRALQDL VAEGDSGLSL QIQKFATFTE KLLLGNALCV
SPLKNGVNAN AAGFKSLREV ASEVDDEKDF KSFVLSHAPK IASGSTAIKY EKHPTLAAPP
PQPAPIHTVN QPSAAPLPQA PPQLSGPPFN STPPQSATSP VQHQHSPHSY QQPPQQLPQQ
LPYQPPYQPP PPQQDPYGMH QQAPGQMPPQ QQHPQPQPYP PPGPGPAHMP TQYRPYSPVQ
QQQPPPEHLS AARNGFGASP LSEEPGPGPV FGMSLDYLSH RDQTAIPMIV YQCIQAIELF
GLNVEGIYRL SGNANHIAHL KALFDHNFNL VDFTNPENFF HDINSVAGLL KQFFRELPDP
LFMNQHYAEF INAARIDDEE QRRLALHALV NNLPDTNYAT LRALILHLNH VHKRSNENRM
NAGNIAISFG LTLMGSNAGH NVADSGWQAR VIETILLKAE EIFNTE
//
