ID A0A0H1BE67_9EURO Unreviewed; 1157 AA.
AC A0A0H1BE67;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Insulysin {ECO:0000313|EMBL:KLJ09655.1};
GN ORFNames=EMPG_14915 {ECO:0000313|EMBL:KLJ09655.1};
OS Blastomyces silverae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=2060906 {ECO:0000313|EMBL:KLJ09655.1, ECO:0000313|Proteomes:UP000053573};
RN [1] {ECO:0000313|Proteomes:UP000053573}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 139 {ECO:0000313|Proteomes:UP000053573};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLJ09655.1}.
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DR EMBL; LDEV01002297; KLJ09655.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0H1BE67; -.
DR STRING; 2060906.A0A0H1BE67; -.
DR OrthoDB; 129328at2759; -.
DR Proteomes; UP000053573; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 2.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000053573};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 33..105
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 159..213
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 239..418
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 424..712
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 717..898
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 1157 AA; 130179 MW; 76DBB40C4358DC3E CRC64;
MAIVERLAED LEKPSVDDRS YRVIRLPNKL EALLVHDPDT DKASASVNVN VGNFSDDDDL
PGIAHAVEHA LFMGTKKYLA AHSGHSNAYT AATETNYYFE VAATATAVSK SAQPTTPTTP
SIPAEVEPLT DGLSRLTLPA TTTVADSAAS SSSDLVPPLY GALDRFAQFF IAPLFLESTL
DRELRAVDSE NKKNLQNDAW RLMQLNKSLS NPKHPYHHFS TGNLQTLRDG PQSRGVNVRD
EFIRFYETNY SANRMKLVVL GRESLDELEG WVAELFADVK NKDLPQNRWD DVQPYTPADL
QKVCFAKPVM DTRSLEIFFP YQDEENLYES KPSRYISHLI GHEGPGSILA YIKAKGWAYG
LSAGAMPICP GSAFFTISVR LTEDGINNYH EVIKTIFQYI SILKSRAPEE WIFEEMKNLA
EVDFKFKQKS PASRFTSSLS SVMQKPFPRD WLLSGPNLMR KFDEQAIRRG LDCFRIDNFN
IELVSQTYPG NWDSKEKWYG TEHKVETIPN DLLSEIGRIL EAPSYNPMLE LHLPHRNEFV
PTRLEVEKKE VAEPAKRPTL IRNDDRVRAW FKKDDTFYVP KASVQIVLRN PLAYATPGNN
VLTRIACALI QDDLQEYSYD AELGGLDYNL TASVFGLEVS VSGYNDKMAV LLEKVLHSMR
DFKVKPDRFK VVKERMADAF SNSEYQQPYY QVGNVTRYLT AEKTWITEQL AAELEHIELE
DVAGFFPQLL RQTHIELLGH GNLYKEDVLK MANMVESSFH SRPLPQSQWH VRRNIIVPPG
SNYIYEKTLK DPANINHCIE YYLFVGDLME PQLRAKSLLF GQLTNEPAFD QLRTQEQLGY
VVWSGIRYGA TTLGYRVIIQ SERTNQYLES RIEAFLARFA GTLDGMTDEE FEGHKRSLIN
KRLEKLKNLN SETNRFWSHI GSEYLDFTQH QTDAEKVSEL TKGDMVEFYR QYIDPQSPTR
AKLSIHLNAQ SSVQPKGVDA GAVLNAAADE RKMGVIEQLS NIVSSSLTEF DSEKFKASFA
DANFMTSDIA TNRDAILSAV RGFLETELKL ESEKVASILE PTTNVLDELL QGFGIMSPPS
TTGDATAPAI EKAVNGTING TTNGAMNGHA ATPPAISNPV QPVYITNVPE FKARLAVSAG
PSPIVDLSEF EEIDPKL
//