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Database: UniProt
Entry: A0A0H1BEC8_9EURO
LinkDB: A0A0H1BEC8_9EURO
Original site: A0A0H1BEC8_9EURO 
ID   A0A0H1BEC8_9EURO        Unreviewed;      1019 AA.
AC   A0A0H1BEC8;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   07-NOV-2018, entry version 18.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=EMPG_14848 {ECO:0000313|EMBL:KLJ09725.1};
OS   Emmonsia parva UAMH 139.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=1246674 {ECO:0000313|EMBL:KLJ09725.1, ECO:0000313|Proteomes:UP000053573};
RN   [1] {ECO:0000313|Proteomes:UP000053573}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 139 {ECO:0000313|Proteomes:UP000053573};
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W.,
RA   McEwen J.G., Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KLJ09725.1}.
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DR   EMBL; LDEV01002281; KLJ09725.1; -; Genomic_DNA.
DR   EnsemblFungi; KLJ09725; KLJ09725; EMPG_14848.
DR   Proteomes; UP000053573; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 1.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053573};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:KLJ09725.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053573}.
FT   DOMAIN      425    550       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      719    803       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      897   1019       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   COILED      188    208       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1019 AA;  115807 MW;  0AE9FB86387617A7 CRC64;
     MDSDGEHEPD GLRQADPTEA DLDERYPNRP RNHSPTLPFH DLFLTLFNPL NENKKRPTGP
     AVARRKVGPH GHGAAVHLSP QERRRDIIQR FISRWRKEVG DDIFPAFRLI IPEKDRDRAM
     YGLKEKAIGK LLVKVMKIDK NSEDGFSLLN WKVPGQSFAS RMAGDFAGRC FEVISKRPLR
     TKVGDMTIDE VNEQLDKLSA ASKEDEQVPI LAYFYRRMNP EELMWLIRII LRQMKVGATE
     RTLFNIWHPD AEALFSISSS LRRVCWELYN PDIRLEGDDA KVALMQCFQP QLAQFQMQSF
     ERMIQKMRLA EDDPTFWIEE KLDGERMQLH MESDDSVPGG KRFAFWSRKA KEYTYLYGNG
     FFDENGALTR HLQKAFADGV QSIILDGEMI TWDPEHDAIV PFGTLKSAAL AEQRNPFSTG
     QRPLFRIFDI LFLNGQPLTR YTLKDRRKAL EASVIPVHRR FEIHTYEIGH SAADIEHLLR
     KVVAEASEGL VLKNPNSPYR LNERHDDWMK VKPEYMTEFG ESLDCIVIGG YYGSGRRGGA
     LSSFLCGLRV DGSHAKKGDH PTKCYSFCKV GGGFTAADYA NIRHHTDGKW TDWDPKRPPT
     EYIELAGGDL QYERPDVWIK PEDSVVLCVK ASSVTPSDQF RLGLTVRFPR FKRLRMDKDW
     HSALSIQEFM DLKSNIEKEI KEKEFKVDDS RKPRHRRTTK KPLTVAGYGG GKKTEYAGPS
     GKLFNGLNFF VMTESVHQPK KTKAQLEQLV KANGGKIYQT NTAAENTICI ADRRTVKVAS
     LQKNAKENVI RPSWLFDCLT QNERDHGLPD LLIPLEPKHM FFTTADQEEE IAGNVDIYSD
     SYARDVDVPE LKKLLDGIAP PPDLPPSHIS QLESQLESHS LNEQDPTTTT ISNNSSSPGW
     LFKGLVIYFA TPPSKSNDDK GEKPHVLTQR LHLASNLVKF AGGEAITDDS GMKDPRVTHI
     VVDNTTSGDK AAMAATDVAE IRRAISSRAG VGKQIPHIVS VKWVEESWRE RTLVDEERM
//
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