ID A0A0H1BHC0_9EURO Unreviewed; 667 AA.
AC A0A0H1BHC0;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596, ECO:0000256|PIRNR:PIRNR018300};
GN ORFNames=EMPG_13898 {ECO:0000313|EMBL:KLJ10755.1};
OS Blastomyces silverae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=2060906 {ECO:0000313|EMBL:KLJ10755.1, ECO:0000313|Proteomes:UP000053573};
RN [1] {ECO:0000313|Proteomes:UP000053573}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 139 {ECO:0000313|Proteomes:UP000053573};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also
CC known as the alpha DNA polymerase-primase complex) which plays an
CC essential role in the initiation of DNA synthesis.
CC {ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC {ECO:0000256|ARBA:ARBA00007299, ECO:0000256|PIRNR:PIRNR018300}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLJ10755.1}.
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DR EMBL; LDEV01001911; KLJ10755.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0H1BHC0; -.
DR STRING; 2060906.A0A0H1BHC0; -.
DR OrthoDB; 49016at2759; -.
DR Proteomes; UP000053573; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.60; -; 2.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR016722; DNA_pol_alpha_bsu.
DR InterPro; IPR013627; Pol_alpha_B_N.
DR PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF08418; Pol_alpha_B_N; 1.
DR PIRSF; PIRSF018300; DNA_pol_alph_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR018300}; Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053573}.
FT DOMAIN 22..266
FT /note="DNA polymerase alpha subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08418"
FT DOMAIN 373..610
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 116..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 72885 MW; C4E2D9D0E62CD0F4 CRC64;
MEETKSELDD AFSGSCPSGV PQDVAAELRS IMRLHSMSAQ DLSYKWDAYC LKMGAEETTL
NLDTVRGLKR DVQDALERES RGKTHMRGAD KRNAISATPR AAANTRDVFG MLDDFASSPQ
DRTTNGAGAS AVKRKAAFET STASKMGRVE KRTGSLVDSK TPTRPSNGDP TRLLSTPFSE
RQNSGQVLET INSHLSQPQP PVAPYPSERI KPTANTDMKK FAYKPMSMHL NEASEVLDNM
IDEFTDIIQK HHGLDDTVFG SAANQSTKEI IAVGRIASDS LEGKLNTASL VLETSRRTGA
GLRIPLKVDS LPSVQLFPGQ IVALRGINAS REYFTVFEVL STPLLPPAAS PPAIIQSIND
RLGDNDAERA LHILIASGPF TADDNLDFEP LRALCLKAAD ECADALILTG PFLDLEHPLI
ASGDFDLPDV KGLDPDNATL SSLFRCYITP LLKQLVSAVP SICIFLIPSV RDAVSKHVSF
PQERLPKKDL DLSQTKQVRT VPNPVTLSLN ESVFGMCSHD VLFELRQEEV VGGKPSEGGL
LTRLSRYLIE QRHFLPVFPT SARENLPKSG VEGGLATGAM LDISYLKLGE WWNARPDVLI
TPSILPPFVK VVEGVLVINP GTLSKRKAAG SYARMTLHPR TLTEEEMNVK QVGHNVYERA
RVDVIRI
//
