ID A0A0H1BHQ1_9EURO Unreviewed; 679 AA.
AC A0A0H1BHQ1;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Pre-mRNA-splicing factor CLF1 {ECO:0000313|EMBL:KLJ08711.1};
GN ORFNames=EMPG_15865 {ECO:0000313|EMBL:KLJ08711.1};
OS Blastomyces silverae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=2060906 {ECO:0000313|EMBL:KLJ08711.1, ECO:0000313|Proteomes:UP000053573};
RN [1] {ECO:0000313|Proteomes:UP000053573}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 139 {ECO:0000313|Proteomes:UP000053573};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC Required for the spliceosome assembly and initiation of the DNA
CC replication. {ECO:0000256|ARBA:ARBA00037040}.
CC -!- SUBUNIT: Associated with the spliceosome.
CC {ECO:0000256|ARBA:ARBA00011524}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the crooked-neck family.
CC {ECO:0000256|ARBA:ARBA00008644}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLJ08711.1}.
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DR EMBL; LDEV01002545; KLJ08711.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0H1BHQ1; -.
DR STRING; 2060906.A0A0H1BHQ1; -.
DR OrthoDB; 5479069at2759; -.
DR Proteomes; UP000053573; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR11246:SF3; CROOKED NECK-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR11246; PRE-MRNA SPLICING FACTOR; 1.
DR Pfam; PF02184; HAT; 2.
DR Pfam; PF14559; TPR_19; 1.
DR SMART; SM00386; HAT; 15.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW mRNA processing {ECO:0000256|ARBA:ARBA00023187};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Reference proteome {ECO:0000313|Proteomes:UP000053573};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 72..105
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT COILED 515..565
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 679 AA; 82001 MW; 6FBBFEC15BD75654 CRC64;
MEASRGPPRV KNKAPAPQQI SAEQLLREAV DRQEPALQAP TQRFADLEEL HEYQGRKRKE
FEDYVRRNRI SMNNWMRYAQ WELEQKEFRR ARSVFERALD VDPTAIVLWI RYIEAEMKTR
NINHARNLLD RAVTILPRVD KLWYKYVYME EMLGNIAGTR QVFERWMSWE PDEGAWGAYI
KLEKRYNEFD RVRAIFERFT VVHPEPKNWI KWARFEEEYG TSDLVREVYG LAIETLGEDF
MDEKLFIAYA RYEAKLKEFE RARAIYKYAL DRLPRSKSIA LHKAYTTFEK QFGDREGVED
VILAKRRVQY EEQIKENPKN YDIWFDFVRL EETSGDVDRV RDVYERAIAQ IPPSQEKRHW
RRYIYLWIFY ALWEELETKD MERARQIYQE CIKLIPHKKF TFAKIWLMKA QFELRQMDLQ
AARKTLGHAI GACPKDKLFK GYIDLERQLF EFLRCRKLFE KQIEWNPANC QAWIKFAELE
RGLDDVDRAR AIYELGISQP VLDMPELLWK SYIDFEEYEG EYDRTRTLYE RLLEKTDHVK
VWINYARFEI NIPEGEEEEE EEEEEKPVSE EAKRRARKVF ERAHNVFKEK EMKEERVALL
NAWKSFEQTH GSPDDIAKIE RQMPSKVKKR RKLDDDRYEE YMDYMFPADD ESSAKLSQIL
QRAHQWKKQQ ASSMGKGEA
//
