ID   A0A0H1BMB3_9EURO        Unreviewed;      1347 AA.
AC   A0A0H1BMB3;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=5-oxoprolinase (ATP-hydrolysing) {ECO:0000313|EMBL:KLJ12659.1};
GN   ORFNames=EMPG_12332 {ECO:0000313|EMBL:KLJ12659.1};
OS   Blastomyces silverae.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=2060906 {ECO:0000313|EMBL:KLJ12659.1, ECO:0000313|Proteomes:UP000053573};
RN   [1] {ECO:0000313|Proteomes:UP000053573}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 139 {ECO:0000313|Proteomes:UP000053573};
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA   Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KLJ12659.1}.
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DR   EMBL; LDEV01000762; KLJ12659.1; -; Genomic_DNA.
DR   STRING; 2060906.A0A0H1BMB3; -.
DR   OrthoDB; 674at2759; -.
DR   Proteomes; UP000053573; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR049517; ACX-like_C.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF19278; Hydant_A_C; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053573}.
FT   DOMAIN          11..232
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          252..559
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          575..753
FT                   /note="Acetophenone carboxylase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19278"
FT   DOMAIN          778..1314
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
SQ   SEQUENCE   1347 AA;  146693 MW;  6CB62F3BEDB860C6 CRC64;
     MAAPVQRRGI RIAIDRGGTF TDCVGNPGSG KLEDDIVIKL LSEDPNHYDD APLEGIRRLL
     SQFGGREIPR GEPLDTSKIE SIRMGTTVAT NALLERKGER MALVVTSGFK DCLEIGNQSR
     PKIFDLAIHR PDVLYEKVIE VDERVTLEDY TEDPIRHSTP TLPRDQSPPD AEIVRGLSSE
     AVRILRRPSE STVKTQLQAL YDEGFRSIAV CLMHGYTFPD HEVMIGRLAR QTGFDHISLS
     HELMPMIKLV PRATSACADA YLTPTIRKYI SGFQSGFEGG LGTSSLKREH GSKGSRCEFM
     QSDGGLVDID NFSGLRAILS GPAGGVVGYA LTSYDPRTDI PVIGFDMGGT STDVSRYGSG
     RYEHVFETTT AGVTIQSPQL DINTVAAGGG SRLFYRNGLF VVGPESAGAH PGPACYRKNG
     PLTVTDANLF LGRLLPDFFP KIFGPKENEG LDAHASAILF EELTETINEE LPEDQKMTPD
     EVAYGFIQIA NESMTRPIRS LTEAKGHDTS KHRLATFGGA GGQHAVAIAE NLGIKQIFVH
     RYSSVLSAYG MALADVVDES QVPESKVWSD GGSTITELKQ KMDTLKEGAR GRLHDQGFED
     KSIVFEEYLN MRYRGTESAL MIINPKSQVA AEGSDNGSDW AYGKGFVQQH EQEFGFTLPD
     RDIIVDDVRV RAIGKSFDDL GKTVDQQLEE AKPQDVGDEK KFGVSQVYFE GGRRKTPIYK
     LEDLNVNDRI YGPAILADGT QTLVITPGAT ALVIETHVVI NIGASEFRDT KISLNTVDPV
     MLSIFGHRFM AIAEQMGRAL QKTSVSTNVK ERLDYSCALF DSDGGLVANA PHLPVHLGSM
     STCVRTQSKI WAGKLKPGDV IVSNHPEFGG THLPDITVIT PAFNGNKIIF YVASRAHHAD
     IGGILPGSMP PHSKELSQEG AAIKSEKLVS EGIFNEERIT HLLYHEPAQY PGCSGTRCLA
     DNINDLKAQI AANQKGINLI SMLINEYGED TVQFYMNSIQ DNAELSVRNL LKTVSDRFAG
     ADLVAVDYMD DGSPIHLKIT IDAEKGEAVF DFEGTGPEVY GNINAPEAVT YSAIIYCLRC
     LISEDIPLNQ GCLKPINVRI PKNSFLSPSD TAAVVGGNVL TSQRVTDVIL KCFQACAASQ
     GDTNNLTFGY GGNVSGEEET KGFGYYETIA GGSGAGPDWE GTSGVHTHMT NTRITDSEVF
     ERRYPVLIRE FSLRPGSGGD GQHRGGDGVI RDIEFRIPVQ VSILSERRVY HPYGLNGGKD
     GQCGLNIWVR RTPKRGQPGE WEVREINLGA KNTAKMFPGD RIVVNTPGGG GWGKVGEESK
     ARKGRDLKHA WKGGSLASRI ETQETSA
//