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Database: UniProt
Entry: A0A0H1R9P0_9RHIZ
LinkDB: A0A0H1R9P0_9RHIZ
Original site: A0A0H1R9P0_9RHIZ 
ID   A0A0H1R9P0_9RHIZ        Unreviewed;       524 AA.
AC   A0A0H1R9P0;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   28-MAR-2018, entry version 19.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN   ORFNames=AA309_19580 {ECO:0000313|EMBL:KLK91591.1};
OS   Microvirga vignae.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Microvirga.
OX   NCBI_TaxID=1225564 {ECO:0000313|EMBL:KLK91591.1, ECO:0000313|Proteomes:UP000035489};
RN   [1] {ECO:0000313|EMBL:KLK91591.1, ECO:0000313|Proteomes:UP000035489}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BR3299 {ECO:0000313|EMBL:KLK91591.1,
RC   ECO:0000313|Proteomes:UP000035489};
RA   Zilli J.E., Passos S.R., Leite J., Baldani J.I., Xavier G.R.,
RA   Rumjaneck N.G., Simoes-Araujo J.L.;
RT   "Draft genome sequence of Microvirga vignae strain BR3299, a novel
RT   nitrogen fixing bacteria isolated from Brazil semi-aired region.";
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|SAAS:SAAS00984457}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KLK91591.1}.
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DR   EMBL; LCYG01000053; KLK91591.1; -; Genomic_DNA.
DR   RefSeq; WP_047190690.1; NZ_LCYG01000053.1.
DR   EnsemblBacteria; KLK91591; KLK91591; AA309_19580.
DR   PATRIC; fig|1225564.3.peg.5219; -.
DR   Proteomes; UP000035489; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000035489};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035489}.
FT   DOMAIN       13    106       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      130    498       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
SQ   SEQUENCE   524 AA;  57501 MW;  EC95C7A903815D56 CRC64;
     MFAEKVPSNA HEWSVSDLAG ALKRTLEDAF GFVRLRGEVS GYRGPHSSGH AYFCLKDQNA
     RIDAVIWKGS FAKLKIRPEE GMEVIATGRI TTFPGSSKYQ IVVDTLEPAG IGALMALLEE
     RRRKLTAEGL FAAERKRRLP FLPRVIGVVT SPTGAVIRDI LHRLEDRFPR HVLVWPVRVQ
     GDTCAAEVAA AIRGFNALRP GGKVPRPDVL IVARGGGSIE DLWGFNEEIV VRAAAESDIP
     LVSAVGHETD TTLIDYAADV RAPTPTGAAE MVVPVRVELM AGVNDLSRRH TETMLRVIER
     RRSDLRATAR ALPTPEALFS PKRQRLDLAA TKLYPALSRN ARGHEERLLK VARQLAHVSP
     VANVARMRAK LDAVGSRPYN AVCRLVTLRE ETLKQIGRRL VVSREALLRA ERTRIAQSTE
     LTQRVAERLV PALKGQLARK ADRLEAVSKL FDSLNYKSVL KRGFALVRDA EGQPLRSADA
     VLDGQALVLE FADGKVDATG GRIGSRPKPA KPKLVATEEQ GALF
//
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