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Database: UniProt
Entry: A0A0H1S2Y0_9MOLU
LinkDB: A0A0H1S2Y0_9MOLU
Original site: A0A0H1S2Y0_9MOLU 
ID   A0A0H1S2Y0_9MOLU        Unreviewed;       355 AA.
AC   A0A0H1S2Y0;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   08-MAY-2019, entry version 21.
DE   RecName: Full=Thymidylate kinase {ECO:0000256|HAMAP-Rule:MF_00165};
DE            EC=2.7.4.9 {ECO:0000256|HAMAP-Rule:MF_00165};
DE   AltName: Full=dTMP kinase {ECO:0000256|HAMAP-Rule:MF_00165};
GN   Name=tmk {ECO:0000256|HAMAP-Rule:MF_00165,
GN   ECO:0000313|EMBL:KLL01705.1};
GN   ORFNames=MRERC_10c017 {ECO:0000313|EMBL:KLL01705.1};
OS   Mycoplasmataceae bacterium RC_NB112A.
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae;
OC   unclassified Mycoplasmataceae.
OX   NCBI_TaxID=1524337 {ECO:0000313|EMBL:KLL01705.1};
RN   [1] {ECO:0000313|EMBL:KLL01705.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RC_NB112A {ECO:0000313|EMBL:KLL01705.1};
RX   PubMed=25964324; DOI=10.1073/pnas.1501676112;
RA   Naito M., Morton J.B., Pawlowska T.E.;
RT   "Minimal genomes of mycoplasma-related endobacteria are plastic and
RT   contain host-derived genes for sustained life within Glomeromycota.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:7791-7796(2015).
CC   -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC       salvage pathways of dTTP synthesis. {ECO:0000256|HAMAP-
CC       Rule:MF_00165}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00165, ECO:0000256|SAAS:SAAS01114966};
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family.
CC       {ECO:0000256|RuleBase:RU003476}.
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000256|SAAS:SAAS01070220}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KLL01705.1}.
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DR   EMBL; JPXG01000010; KLL01705.1; -; Genomic_DNA.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR020476; Nudix_hydrolase.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   InterPro; IPR020084; NUDIX_hydrolase_CS.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018095; Thymidylate_kin_CS.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   Pfam; PF00293; NUDIX; 1.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   PRINTS; PR00502; NUDIXFAMILY.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR   PROSITE; PS51462; NUDIX; 1.
DR   PROSITE; PS00893; NUDIX_BOX; 1.
DR   PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070209};
KW   Hydrolase {ECO:0000256|RuleBase:RU003476,
KW   ECO:0000256|SAAS:SAAS00025287};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070206, ECO:0000313|EMBL:KLL01705.1};
KW   Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070211};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070205};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070204}.
FT   DOMAIN      207    341       Nudix hydrolase. {ECO:0000259|PROSITE:
FT                                PS51462}.
FT   NP_BIND       9     16       ATP. {ECO:0000256|HAMAP-Rule:MF_00165}.
SQ   SEQUENCE   355 AA;  41428 MW;  0658CF3928247482 CRC64;
     MSLLITIEGI DGSGKTTLIN NLKKDPKLNL ITRNWRDTEL GKKVWHLLNE AKAEGKDGLP
     SNWSYIFLIL IAFDELNKKI VQPKLTENKT VIIDRYLDST FVYQGLIGDI GINAIQEVAQ
     KTINLPLPDI TFILDIDPLQ AQQRLNKRKL ETGEYTNWDN LNLEFHRQIR NYYLTLGKYF
     PERVYILDAN RSEAEIATEV SQIIQQTISP PVNLPQFSRV IIPNEKRELL LVKDKWGWNF
     PGGKLEPGET PLQAAKREVF EETNLVIESL EKIGEKNIFF ANIPNSEKQV WKAHFYQAKG
     YSDEIQNKEK EKILEIKFWD PNSPETSEKQ HPYRFYLDII KRMDKSHNLP KIWKY
//
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