ID   A0A0H2LWC5_VARPD        Unreviewed;       341 AA.
AC   A0A0H2LWC5;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha {ECO:0000313|EMBL:KLN54533.1};
DE            EC=1.1.1.- {ECO:0000313|EMBL:KLN54533.1};
GN   Name=acoA {ECO:0000313|EMBL:KLN54533.1};
GN   ORFNames=VPARA_41740 {ECO:0000313|EMBL:KLN54533.1};
OS   Variovorax paradoxus.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=34073 {ECO:0000313|EMBL:KLN54533.1, ECO:0000313|Proteomes:UP000035170};
RN   [1] {ECO:0000313|EMBL:KLN54533.1, ECO:0000313|Proteomes:UP000035170}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TBEA6 {ECO:0000313|EMBL:KLN54533.1,
RC   ECO:0000313|Proteomes:UP000035170};
RA   Poehlein A., Schuldes J., Wuebbeler J.H., Hiessl S., Steinbuechel A.,
RA   Daniel R.;
RT   "Genome sequence of Variovorax paradoxus TBEA6.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KLN54533.1}.
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DR   EMBL; JZWI01000022; KLN54533.1; -; Genomic_DNA.
DR   RefSeq; WP_021012911.1; NZ_JZWI01000022.1.
DR   AlphaFoldDB; A0A0H2LWC5; -.
DR   PATRIC; fig|34073.19.peg.4275; -.
DR   Proteomes; UP000035170; Unassembled WGS sequence.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:KLN54533.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035170}.
FT   DOMAIN          45..325
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
SQ   SEQUENCE   341 AA;  35063 MW;  0621DD3C5095BDDF CRC64;
     MDPSNSGRSS GTALYRTMVR IRAFENAAET ASQGGVSAYG QQAAGAAKVR GPLHLSTGQE
     AVPAGVCAHL RTSDYLTSTH RGHGHTLAKG ADLARMMCEL FGKATGFNGG KGGSMHIADF
     SVGMLGANGV VAAGLPIAVG AAHAQKLLRK SDDITVCFFG DGAINRGPFL EALNWARVYA
     LPVLFVCEDN RWSATTASGP MTAGDGASAR AASMDIAATQ VDGNDVFAVH ETAARLVAEV
     RGGGGPRLLH ALTYRVKGHV SVDLAAYRDP AELAAALETD PIARARGHLL DMGVAAATLD
     AIENAARDEV DSALAIAEAA PWPEPGAAFT DVQTTGAGQW T
//