ID A0A0H2MBU5_VARPD Unreviewed; 671 AA.
AC A0A0H2MBU5;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Acetyl-coenzyme A synthetase {ECO:0000313|EMBL:KLN58142.1};
DE EC=6.2.1.1 {ECO:0000313|EMBL:KLN58142.1};
GN Name=acsA1 {ECO:0000313|EMBL:KLN58142.1};
GN ORFNames=VPARA_06850 {ECO:0000313|EMBL:KLN58142.1};
OS Variovorax paradoxus.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=34073 {ECO:0000313|EMBL:KLN58142.1, ECO:0000313|Proteomes:UP000035170};
RN [1] {ECO:0000313|EMBL:KLN58142.1, ECO:0000313|Proteomes:UP000035170}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TBEA6 {ECO:0000313|EMBL:KLN58142.1,
RC ECO:0000313|Proteomes:UP000035170};
RA Poehlein A., Schuldes J., Wuebbeler J.H., Hiessl S., Steinbuechel A.,
RA Daniel R.;
RT "Genome sequence of Variovorax paradoxus TBEA6.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLN58142.1}.
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DR EMBL; JZWI01000004; KLN58142.1; -; Genomic_DNA.
DR RefSeq; WP_047783285.1; NZ_JZWI01000004.1.
DR AlphaFoldDB; A0A0H2MBU5; -.
DR PATRIC; fig|34073.19.peg.693; -.
DR Proteomes; UP000035170; Unassembled WGS sequence.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KLN58142.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000035170}.
FT DOMAIN 27..80
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 91..479
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
SQ SEQUENCE 671 AA; 73478 MW; 7A63AA268DC80BA0 CRC64;
MPAPNIPQIR LYQDWLRDQR GQSFDTYDAL WRWSVTDLDA FWQSIWDYIG IASPTPHTAV
LADDRMPGAR WFPGAQGNYA REVLRHADAA HAAGMAAIVS DNELGEVREM PWPELRRQVA
SVALTLKSLG VQRGDRVAAY LPNVPETMVA FLACSSIGAV WSVCAPDMGT AAVVDRFRQI
EPKLLIAADG VHYGAKPIDR SAVVQELRDA LPSVQKLLLL RTPHAAQQLA ADADWQGAIA
RSDAEVAAFE PEWLPFDHPI WIVYSSGTTG LPKPIVHGQG GIIMTMYACG LHNDIGASYG
ANNFDERFHW YSSTGWVMWN CQLAGLAFGA TIVIYDGHPA GSKEKPDWGV LWRFVAKHRI
SFFGAGAAYF TNCMKAGVVA AECGDLSRVR ALGSTGSPLS EEVQRWGTAQ LLAAGASSVW
WCNISGGTDF CGAFVGGNRE LPEVPGQMQC RQIGHAVEAW NENGKPVIGE VGELVCTRPI
PSMPLYFWGD EGNARYLSSY FDTYPGVWRH GDWIRIGEDG GCIIYGRSDA TINRQGLRMG
TSEIYSAVEA LPEVLDSMVV DLEYLGRESY MPLFVVLRPG AALDDAMRAK INNAIKTSLS
PRFLPNDIFQ VAEIPRTLSG KKQELPIKKL LLGQPLEKVV NREAMANPGS LGWYVEFAAR
RAAASQGISS S
//
