ID   A0A0H2UZ70_SHIFL        Unreviewed;       680 AA.
AC   A0A0H2UZ70;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Carboxy-terminal protease for penicillin-binding protein 3 {ECO:0000313|EMBL:AAN42996.2};
GN   Name=prc {ECO:0000313|EMBL:AAN42996.2};
GN   OrderedLocusNames=SF1395 {ECO:0000313|EMBL:AAN42996.2};
OS   Shigella flexneri.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623 {ECO:0000313|EMBL:AAN42996.2, ECO:0000313|Proteomes:UP000001006};
RN   [1] {ECO:0000313|EMBL:AAN42996.2, ECO:0000313|Proteomes:UP000001006}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a {ECO:0000313|Proteomes:UP000001006};
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
CC   -!- SIMILARITY: Belongs to the peptidase S41A family.
CC       {ECO:0000256|ARBA:ARBA00009179, ECO:0000256|RuleBase:RU004404}.
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DR   EMBL; AE005674; AAN42996.2; -; Genomic_DNA.
DR   RefSeq; NP_707289.4; NC_004337.2.
DR   AlphaFoldDB; A0A0H2UZ70; -.
DR   PaxDb; 198214-SF1395; -.
DR   GeneID; 1024381; -.
DR   KEGG; sfl:SF1395; -.
DR   PATRIC; fig|198214.7.peg.1645; -.
DR   HOGENOM; CLU_016199_1_0_6; -.
DR   Proteomes; UP000001006; Chromosome.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00988; PDZ_CTP_protease; 1.
DR   CDD; cd07560; Peptidase_S41_CPP; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 3.30.750.44; -; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004447; Peptidase_S41A.
DR   InterPro; IPR005151; Tail-specific_protease.
DR   InterPro; IPR020992; Tail_Prtase_C.
DR   InterPro; IPR040573; TSP_N.
DR   NCBIfam; TIGR00225; prc; 1.
DR   PANTHER; PTHR32060; TAIL-SPECIFIC PROTEASE; 1.
DR   PANTHER; PTHR32060:SF32; TAIL-SPECIFIC PROTEASE; 1.
DR   Pfam; PF11818; DUF3340; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF03572; Peptidase_S41; 1.
DR   Pfam; PF17804; TSP_NTD; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00245; TSPc; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|RuleBase:RU004404};
KW   Protease {ECO:0000256|RuleBase:RU004404, ECO:0000313|EMBL:AAN42996.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001006};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825,
KW   ECO:0000256|RuleBase:RU004404}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..680
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002599817"
FT   DOMAIN          236..306
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
SQ   SEQUENCE   680 AA;  76438 MW;  4EDF82E2646833B5 CRC64;
     MFFRLTALAG LLAIAGQTFA VEDITRADQI PVLKEETQHA TVSERVTSRF TRSHYRQFDL
     DQAFSAKIFD RYLNLLDYSH NVLLASDVEQ FAKKKTELGD ELRSGKLDVF YDLYNLAQKR
     RFERYQYALS VLEKPMDFTG NDTYNLDRSK APWPKNEAEL NAQWDSKVKF DELSLKLTGK
     TDKEIRETLT RRYKFAIRRL AQTNSEDVFS LAMTAFAREI DPHTNYLSRR NTEQFNTEMS
     LSLEGIGAVL QMDDDYTVIN SMVAGGPAAK SKAISVGAKI VGVGQTGKPM VDVIGWRLDD
     VVALIKGPKG SKVRLEILPA GKGTKTRTVT LTRERIRLED RAVKMSVKTV GKEKVGVLDI
     PGFYVGLTDD VKVQLQKLEK QNVSSVIIDL RSNGGGALTE AVSLSGLFIP AGPIVQVRDN
     NGKVREDSDT DGQVFYKGPL VVLVDRFSAS ASEIFAAAMQ DYGRALVVGE PTFGKGTVQQ
     YRSLNRIYDQ MLRPEWPALG SVQYTIQKFY RVNGGSTQRK GVTPDIIMPT GNEETETGEK
     FEDNALPWDS IDAATYVKSG DLTAFEPELL KEHNARIAKD PEFQNIMKDI ARFNAMKDKR
     NIVSLNYAVR EKENNEDDAT RLARLNERFK REGKPELKKL DDLSKDYQEP DPYLDETVNI
     ALDLAKLEKA RPAEQPAPVK
//