ID A0A0H3C8X1_CAUVN Unreviewed; 469 AA.
AC A0A0H3C8X1;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Glucosylceramidase {ECO:0000313|EMBL:ACL95298.1};
DE EC=3.2.1.45 {ECO:0000313|EMBL:ACL95298.1};
GN OrderedLocusNames=CCNA_01833 {ECO:0000313|EMBL:ACL95298.1};
OS Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=565050 {ECO:0000313|EMBL:ACL95298.1, ECO:0000313|Proteomes:UP000001364};
RN [1] {ECO:0000313|EMBL:ACL95298.1, ECO:0000313|Proteomes:UP000001364}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA1000 / CB15N {ECO:0000313|Proteomes:UP000001364};
RX PubMed=20472802; DOI=10.1128/JB.00255-10;
RA Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA Walunas T.L., Crosson S.;
RT "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL J. Bacteriol. 192:3678-3688(2010).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 30 family.
CC {ECO:0000256|ARBA:ARBA00005382, ECO:0000256|RuleBase:RU361188}.
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DR EMBL; CP001340; ACL95298.1; -; Genomic_DNA.
DR RefSeq; WP_010919625.1; NC_011916.1.
DR RefSeq; YP_002517206.1; NC_011916.1.
DR AlphaFoldDB; A0A0H3C8X1; -.
DR SMR; A0A0H3C8X1; -.
DR GeneID; 7331381; -.
DR KEGG; ccs:CCNA_01833; -.
DR PATRIC; fig|565050.3.peg.1799; -.
DR HOGENOM; CLU_014379_3_1_5; -.
DR OrthoDB; 9806701at2; -.
DR PhylomeDB; A0A0H3C8X1; -.
DR Proteomes; UP000001364; Chromosome.
DR GO; GO:0004348; F:glucosylceramidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR033452; GH30_C.
DR InterPro; IPR001139; Glyco_hydro_30.
DR InterPro; IPR033453; Glyco_hydro_30_TIM-barrel.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR11069; GLUCOSYLCERAMIDASE; 1.
DR PANTHER; PTHR11069:SF23; LYSOSOMAL ACID GLUCOSYLCERAMIDASE; 1.
DR Pfam; PF02055; Glyco_hydro_30; 1.
DR Pfam; PF17189; Glyco_hydro_30C; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361188, ECO:0000313|EMBL:ACL95298.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361188};
KW Reference proteome {ECO:0000313|Proteomes:UP000001364};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..469
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002606261"
FT DOMAIN 69..404
FT /note="Glycosyl hydrolase family 30 TIM-barrel"
FT /evidence="ECO:0000259|Pfam:PF02055"
FT DOMAIN 407..467
FT /note="Glycosyl hydrolase family 30 beta sandwich"
FT /evidence="ECO:0000259|Pfam:PF17189"
SQ SEQUENCE 469 AA; 50930 MW; AA9BB47DE7F97C5B CRC64;
MRLRLLSITV AALAATSPVL AAPKLRAWVT TGDKSQLLAA QAPVAASSAE ALAGLPVIAV
DAQERHQSIV GFGASITDAS AWLIQNKLKP ADRDALLREL FGRGAGGLGF SFTRVTIGAS
DFSLDHYSLN DTPDGAPDPE LKHFSLARPK QHVFPTVRAA LKINPELKVM ASPWSAPAWM
KTTGSLLKGQ LKAEAYPVYA TFFARYVQEA AKVGVPTDYL SVQNEPDFEP ENYPGMRWLP
QDRARFFGEH LAPVFKRDKI KTRVLDWDHN WDQPQQPLTV LADPKARAFL TGVAWHCYAG
EVSAQDKVRA AYPDKEVFFT ECSGGEWAPK FDDSFAWMVE QLIIGSTRGG ARGVLMWNLA
LDEKFGPHAG GCGDCRGVVS IDSQTGALTR TQEYYAFGHA SRFVKPDAVR IGSPAKVEGL
RTVAFQNPDG QRVLIVLNVS TAAVDFAIAS AGARFKASLP ARSAGTFVW
//
