ID A0A0H3CCP7_CAUVN Unreviewed; 1022 AA.
AC A0A0H3CCP7;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Cation/multidrug efflux pump acrB5 {ECO:0000313|EMBL:ACL96684.1};
GN Name=acrB5 {ECO:0000313|EMBL:ACL96684.1};
GN OrderedLocusNames=CCNA_03219 {ECO:0000313|EMBL:ACL96684.1};
OS Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=565050 {ECO:0000313|EMBL:ACL96684.1, ECO:0000313|Proteomes:UP000001364};
RN [1] {ECO:0000313|EMBL:ACL96684.1, ECO:0000313|Proteomes:UP000001364}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA1000 / CB15N {ECO:0000313|Proteomes:UP000001364};
RX PubMed=20472802; DOI=10.1128/JB.00255-10;
RA Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA Walunas T.L., Crosson S.;
RT "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL J. Bacteriol. 192:3678-3688(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001340; ACL96684.1; -; Genomic_DNA.
DR RefSeq; WP_010920956.1; NC_011916.1.
DR RefSeq; YP_002518592.1; NC_011916.1.
DR AlphaFoldDB; A0A0H3CCP7; -.
DR SMR; A0A0H3CCP7; -.
DR GeneID; 7330813; -.
DR KEGG; ccs:CCNA_03219; -.
DR PATRIC; fig|565050.3.peg.3145; -.
DR HOGENOM; CLU_002755_1_2_5; -.
DR OrthoDB; 9806532at2; -.
DR PhylomeDB; A0A0H3CCP7; -.
DR Proteomes; UP000001364; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001364};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 334..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 859..879
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 886..908
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 914..937
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 958..979
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 985..1006
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1022 AA; 109857 MW; 0CAC5F6315E27AA8 CRC64;
MKFDLSTFAV RRWQFTLVAF GLLVMLGFNA FTSIPRSEDP HFPIPIVIVR AVLPGAEPSE
MEQLVVDPIE DAVDGLDNIE KVESVSLDGA AVVSVHFTWD VDPERKYDQV VREVNAIRGN
LPTGLARLDI QRARTTEVSV VQVALTSDTL PMRRLEKVAD RLRERLDRVP GVREAQYWGA
PPSDVQVTLD LARLSALKLP ATAVTDALRA AGAEAPIGAV QAGERRFNVK SGGAFRDLKT
IGDTPVRSIG GKVVRVSDVA TIGWAQQEPT HVTRFNGKRA VFITVKQKDG QDVAKITQEV
RKVLDEYERA LPAGVKLERA FFQAENVKHR LKNLFRDFGI ALVLVLITLL PLGPRAGVVV
MVSIPLSLLI GLSMLQAFGF TLNQLSIAGF VLSLGLLVDD SIVITENIAR RIREGEERTE
AAVNGARQIG LAVVGCTATL MLAFLPLMAL PAGSGAYIKS LPVTVLCTVG ASLLVSLTII
PFLASRILDK HSDPEGNALL RAVNGGIQRF YRPVLHASLA RPWLALALML ALCATTVPLV
KVIGSSLFPP AETPQFLIRI ETPDGASLAR TDQALRFVDA RLAKEPEILW RASNLGRGNP
QIFYNKTQRE SSNSFAEVYA SFEAWKPGKS DKVLDALRAD FAKYPGARIT VVAFENGPPI
DAPIAIRITG QNLEVLKALA ARTEAALKDT PGARDVSNPM RLDRTDLDLG VDEAKAAALG
VPAGAARRVT RLALSGEEAA RFRDPDGDDY AVRVRLPTAQ VDGAARNPLS ALNGVYVPTA
EGEAAPLGAI ATPTLRSSPA RIDRFDRERT VTVTSYVATG YLTAKVTQDV VQRLEKEVPM
PPGYRLSLGG QAEAQSESFA GLGAAVLVAI FGILAVLVLE FQKFKTALVV AGIIPFGIFG
AVLALALTGN SLSFTATIGL IALIGIEIKN SILLVDFTEQ LRREGMNLHD AIEKAGEVRF
LPVLLTSVTA IGGLLPLALE RSGLYSPLAI AIIGGLITST LLSRVATPVM YWLTARGKAE
AV
//
