ID A0A0H3E7G8_BACA1 Unreviewed; 792 AA.
AC A0A0H3E7G8;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:ADP33790.1};
GN OrderedLocusNames=BATR1942_14340 {ECO:0000313|EMBL:ADP33790.1};
OS Bacillus atrophaeus (strain 1942).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=720555 {ECO:0000313|EMBL:ADP33790.1, ECO:0000313|Proteomes:UP000006867};
RN [1] {ECO:0000313|Proteomes:UP000006867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1942 {ECO:0000313|Proteomes:UP000006867};
RA Gibbons H.S., Broomall S., McNew L.A., Daligault H., Chapman C., Bruce D.,
RA Karavis M., McGregor P., Hong C., Park K.H., Akmal A., Feldman A.,
RA Lin J.S., Chang W.E., Higgs B.W., Demirev P., Lindquist J., Liem A.,
RA Fochler E., Tapia R., Bishop-Lilly K., Detter C., Han C., Sozhamannan S.,
RA Rosenzweig C.N., Skowronski E.;
RT "Genomic signatures of strain selection and enhancement in Bacillus
RT atrophaeus subsp. Globigii, a historical biowarfare simulant.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADP33790.1, ECO:0000313|Proteomes:UP000006867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1942 {ECO:0000313|EMBL:ADP33790.1,
RC ECO:0000313|Proteomes:UP000006867};
RX PubMed=21464989; DOI=10.1371/journal.pone.0017836;
RA Gibbons H.S., Broomall S.M., McNew L.A., Daligault H., Chapman C.,
RA Bruce D., Karavis M., Krepps M., McGregor P.A., Hong C., Park K.H.,
RA Akmal A., Feldman A., Lin J.S., Chang W.E., Higgs B.W., Demirev P.,
RA Lindquist J., Liem A., Fochler E., Read T.D., Tapia R., Johnson S.,
RA Bishop-Lilly K.A., Detter C., Han C., Sozhamannan S., Rosenzweig C.N.,
RA Skowronski E.W.;
RT "Genomic signatures of strain selection and enhancement in Bacillus
RT atrophaeus var. globigii, a historical biowarfare simulant.";
RL PLoS ONE 6:E17836-E17836(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; CP002207; ADP33790.1; -; Genomic_DNA.
DR RefSeq; WP_003327006.1; NC_014639.1.
DR AlphaFoldDB; A0A0H3E7G8; -.
DR GeneID; 23411309; -.
DR KEGG; bae:BATR1942_14340; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_010448_0_0_9; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000006867; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 7..205
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 208..306
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 792 AA; 86896 MW; D40E2D73218EE0BE CRC64;
MHKQIKKAAV LGSGVMGSGI AAHLANIGIP VLLLDIVPNE LTKDDMKKGR TVDSPEVRSR
LSQTAVKKLL KQKPAPLTSA KNISYITPGN LEDDAEKLNE ADWIIEVVVE NLEVKKQIFS
LVDEHRKPGS IISSNTSGIS VQDMAEGRSD DFKAHFLGTH FFNPARYLKL LEIIPIQETA
PDVVSFMKSF GENVLGKGVV AAKDTPNFIA NRIGTYGLLV TVQEMLKGGY QIGEVDSVTG
PLIGRPKSAT FRTLDVVGLD TFAHVARNVY DKAEGEEKDV FRLPDFMNKM LENGWIGSKA
GQGFYKKEGK AIYELDPLTL TYGERTKMRT AGLEAVKQVK GIKSKMKALI YSEDRAGQLL
WNITSPTLLY SAQLTGEIAD HILAIDQAMK WGFGWELGPF EMWDAIGVRQ SAEKLEQEGA
AIPGWIKEML DKGHETFYIK ENGSLFYYDR GEYRAVKENK KRLHLASLKE SKGVIAKNSG
ASLIDIGDDV ALLEFHSKSN AIGLDIIQMI NKALEETDRH YKGLVIGNQG KNFCVGANLA
MILMEAQDDN YAEVDLVIRR FQETMMNIKY SSKPVVAAPF GMTLGGGTEV CLPAARIQAA
SESYMGLVES GVGLIPGGGG NKELYCRHLR GLQDGADIMP AAIKTFETIA MAKVSSSAQE
AREMNILSEV DHISINQDHL LYDAKKLAAS LYDNGYRPPA RQKIKVTGAT GYAALLLGAE
QMKLSGYLSE HDMKIAKKLA NVIAGGKVPF GTEVEEDYLL EIEREAFLSL AGEAKSQARM
QHMLVKGKPL RN
//