ID A0A0H3FI36_KLEAK Unreviewed; 453 AA.
AC A0A0H3FI36;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Citrate-sodium symporter {ECO:0000256|PIRNR:PIRNR005348};
GN OrderedLocusNames=EAE_00045 {ECO:0000313|EMBL:AEG94948.1};
OS Klebsiella aerogenes (strain ATCC 13048 / DSM 30053 / CCUG 1429 / JCM 1235
OS / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006 / CDC 819-56)
OS (Enterobacter aerogenes).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=1028307 {ECO:0000313|EMBL:AEG94948.1, ECO:0000313|Proteomes:UP000008881};
RN [1] {ECO:0000313|Proteomes:UP000008881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 /
RC NCIMB 10102 / NCTC 10006 {ECO:0000313|Proteomes:UP000008881};
RA Shin S.H., Kim S., Kim J.Y., Yang K.-S., Seo J.-S.;
RT "Complete sequence of Enterobacter aerogenes KCTC 2190.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEG94948.1, ECO:0000313|Proteomes:UP000008881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 /
RC NCIMB 10102 / NCTC 10006 {ECO:0000313|Proteomes:UP000008881};
RX PubMed=22493190; DOI=10.1128/JB.00028-12;
RA Shin S.H., Kim S., Kim J.Y., Lee S., Um Y., Oh M.K., Kim Y.R., Lee J.,
RA Yang K.S.;
RT "Complete genome sequence of Enterobacter aerogenes KCTC 2190.";
RL J. Bacteriol. 194:2373-2374(2012).
CC -!- FUNCTION: Uptake of citrate across the boundary membrane with the
CC concomitant uptake of a sodium ion (symport system).
CC {ECO:0000256|PIRNR:PIRNR005348}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR005348}.
CC -!- SIMILARITY: Belongs to the sodium:citrate (SCF) symporter family.
CC {ECO:0000256|PIRNR:PIRNR005348}.
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DR EMBL; CP002824; AEG94948.1; -; Genomic_DNA.
DR RefSeq; WP_013878106.1; NC_015663.1.
DR RefSeq; YP_004590227.1; NC_015663.1.
DR AlphaFoldDB; A0A0H3FI36; -.
DR KEGG; eae:EAE_00045; -.
DR PATRIC; fig|1028307.3.peg.8; -.
DR eggNOG; COG3493; Bacteria.
DR HOGENOM; CLU_041211_0_0_6; -.
DR OrthoDB; 8584824at2; -.
DR Proteomes; UP000008881; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008514; F:organic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006101; P:citrate metabolic process; IEA:UniProtKB-UniRule.
DR InterPro; IPR004679; 2-OHcarboxylate_transport.
DR PANTHER; PTHR40033:SF1; CITRATE-SODIUM SYMPORTER; 1.
DR PANTHER; PTHR40033; NA(+)-MALATE SYMPORTER; 1.
DR Pfam; PF03390; 2HCT; 1.
DR PIRSF; PIRSF005348; YxkH; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|PIRNR:PIRNR005348};
KW Citrate utilization {ECO:0000256|PIRNR:PIRNR005348};
KW Membrane {ECO:0000256|PIRNR:PIRNR005348, ECO:0000256|SAM:Phobius};
KW Symport {ECO:0000256|PIRNR:PIRNR005348};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|PIRNR:PIRNR005348}.
FT TRANSMEM 35..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 453 AA; 47833 MW; FD97F9A718A5F245 CRC64;
MSTNDDSFSV TNHPTEIQRP SLQVRWWNIM DTWKVGIIPL PLFVLAGVLI AIDCLGGNLP
SDIVVMVATL AFFGFACGEF GKRLPIVGKL GAAAICATFI PSALVYYGLL PDAVVESTTK
FYKFTNILYL YICCIIVGSI MSMNRTVLIQ GFLRIFFPML CGEIVGMLVG MGVGLALGLE
PFQIFFFIIL PIMAGGVGEG AIPLSIGYAA LLHMDQGVAL GRVLPMVMLG GLTAIIISGC
LNQLGKRYPH LTGEGQLMPN CANADATVSQ PAFSGKADVT TIASGALLAV LLYMLGMLGH
KLIGLPAPVG MLFMAVLVKL CNGASPRLLE GSQVVYKFFQ TSVTYPILFA VGVAITPWHE
LVAAFTVSNL LVIVSTVSAL VATGFFVGKK IGMHPIDVAI VSCCQSGQGG TGDVAILTAG
NRMSLMPFAQ IATRIGGAIN VSISLLILGN FLI
//
