ID A0A0H3FQT6_KLEAK Unreviewed; 684 AA.
AC A0A0H3FQT6;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=helD {ECO:0000313|EMBL:AEG97988.1};
GN OrderedLocusNames=EAE_15375 {ECO:0000313|EMBL:AEG97988.1};
OS Klebsiella aerogenes (strain ATCC 13048 / DSM 30053 / CCUG 1429 / JCM 1235
OS / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006 / CDC 819-56)
OS (Enterobacter aerogenes).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=1028307 {ECO:0000313|EMBL:AEG97988.1, ECO:0000313|Proteomes:UP000008881};
RN [1] {ECO:0000313|Proteomes:UP000008881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 /
RC NCIMB 10102 / NCTC 10006 {ECO:0000313|Proteomes:UP000008881};
RA Shin S.H., Kim S., Kim J.Y., Yang K.-S., Seo J.-S.;
RT "Complete sequence of Enterobacter aerogenes KCTC 2190.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEG97988.1, ECO:0000313|Proteomes:UP000008881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 /
RC NCIMB 10102 / NCTC 10006 {ECO:0000313|Proteomes:UP000008881};
RX PubMed=22493190; DOI=10.1128/JB.00028-12;
RA Shin S.H., Kim S., Kim J.Y., Lee S., Um Y., Oh M.K., Kim Y.R., Lee J.,
RA Yang K.S.;
RT "Complete genome sequence of Enterobacter aerogenes KCTC 2190.";
RL J. Bacteriol. 194:2373-2374(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP002824; AEG97988.1; -; Genomic_DNA.
DR RefSeq; WP_015704911.1; NC_015663.1.
DR RefSeq; YP_004593267.1; NC_015663.1.
DR AlphaFoldDB; A0A0H3FQT6; -.
DR KEGG; eae:EAE_15375; -.
DR PATRIC; fig|1028307.3.peg.3071; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_006494_0_1_6; -.
DR OrthoDB; 5298826at2; -.
DR Proteomes; UP000008881; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR022161; Helicase_IV_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF63; DNA HELICASE IV; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12462; Helicase_IV_N; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 195..505
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 216..223
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 684 AA; 77903 MW; B27D5985A6F059B6 CRC64;
MELKATTLGK RMAQHPYDRV QLLNAGVKVS GDRHEYLIPF NQLLSVQCKR GLVWGELEFV
LPESKVVRLH GTEWTETQHF FHHLNNLWQQ WSAEMSEIAA DLLRLQLSEI ERASAEGKWL
TRQQVADVQD KIRRALTGLP FPESRLDEFD NCRELWRQCQ CWLSDIDEAR LAHNQAYTEA
MLEQYRGFFD KIESSPLNPA QARAVVNGER SLLVLAGAGS GKTSVLVARA GWLLNRGEAA
ADQILLLAFG RQAAQEMDER IQERLGTDEI AARTFHSLAL HIIQQGSKKV PAISKLENDT
AARQKLLLKA WQQQCQEKKA QAKGWRQWLV DEMEWQIDEG DFWQDRALLR RLAGRLDRWV
SLMRMHGGSQ AEMIASAPEE VRDLFNKRVK LMAPLLKAWK TALKEENAVD FSGLIHQAVN
ILDKGRFVSP WKHILVDEFQ DISPQRAELL AALRRQNKQT TLFAVGDDWQ AIYRFSGAQL
SLTTAFNHYF GEGDCCALDT TYRFNGRIGE IANGFIQQNP HQLAKPLNSL TAGDKKAVTL
LPDDKLDDLL DKLSGYVKPE QRILLLARYH HLKPAALEKA ATRWPHLQLD FMTIHASKGQ
QADFVIVLGL QEGGDAFPAP ARESVMEQAL LPQPEDFPDA EERRLLYVAI TRARLRVWLL
FNKERSSSFV EILQELGVPV ARKP
//
