ID A0A0H3FQV7_KLEAK Unreviewed; 390 AA.
AC A0A0H3FQV7;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Multidrug efflux system protein EmrA {ECO:0000313|EMBL:AEG95227.1};
GN OrderedLocusNames=EAE_01455 {ECO:0000313|EMBL:AEG95227.1};
OS Klebsiella aerogenes (strain ATCC 13048 / DSM 30053 / CCUG 1429 / JCM 1235
OS / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006 / CDC 819-56)
OS (Enterobacter aerogenes).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=1028307 {ECO:0000313|EMBL:AEG95227.1, ECO:0000313|Proteomes:UP000008881};
RN [1] {ECO:0000313|Proteomes:UP000008881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 /
RC NCIMB 10102 / NCTC 10006 {ECO:0000313|Proteomes:UP000008881};
RA Shin S.H., Kim S., Kim J.Y., Yang K.-S., Seo J.-S.;
RT "Complete sequence of Enterobacter aerogenes KCTC 2190.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEG95227.1, ECO:0000313|Proteomes:UP000008881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 /
RC NCIMB 10102 / NCTC 10006 {ECO:0000313|Proteomes:UP000008881};
RX PubMed=22493190; DOI=10.1128/JB.00028-12;
RA Shin S.H., Kim S., Kim J.Y., Lee S., Um Y., Oh M.K., Kim Y.R., Lee J.,
RA Yang K.S.;
RT "Complete genome sequence of Enterobacter aerogenes KCTC 2190.";
RL J. Bacteriol. 194:2373-2374(2012).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP002824; AEG95227.1; -; Genomic_DNA.
DR RefSeq; WP_015370068.1; NC_015663.1.
DR RefSeq; YP_004590506.1; NC_015663.1.
DR AlphaFoldDB; A0A0H3FQV7; -.
DR GeneID; 66602512; -.
DR KEGG; eae:EAE_01455; -.
DR PATRIC; fig|1028307.3.peg.284; -.
DR eggNOG; COG1566; Bacteria.
DR HOGENOM; CLU_018816_15_0_6; -.
DR OrthoDB; 9811754at2; -.
DR Proteomes; UP000008881; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR005694; MFP_proteobact.
DR NCBIfam; TIGR00998; 8a0101; 1.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR PANTHER; PTHR30386:SF19; MULTIDRUG EXPORT PROTEIN EMRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..346
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 169..289
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 122..180
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 390 AA; 42346 MW; 87AD26A1CD43571A CRC64;
MSENAASQTP QQSGSKKGKR KGALLLLTLL FVIVAVAYGI YWFLVLRHYE ETDDAYVAGN
QVQIMAQVSG SVTKVWADNT DFVQQGDPLV TLDQTDAQQA FEKAKTQLAA SVRQTRQQMI
NSKQLQANID VKKTALAQAQ ADLNRRIPLG AANLIGREEL QHARDTVASA QAELDVAIQQ
YNANQAIVLG TKLEQQPAVL QAATEVRNAW LALQRTQIVS PISGYVSRRS VQPGAQIGTT
TPLMAVVPAT NLWVDANFKE TQLAHMRIGQ PATIVSDIYG DDVKYTGKVV GLDMGTGSAF
SLLPAQNATG NWIKVVQRLP VRIEIDAKQL AQHPLRIGLS TLVEVDTSNR EGEMLASQVR
SSPVYESNAR EIGLEPVNKL IDGIIQANAG
//
