UniProt: A0A0H3GGJ2

Database: UniProt
Entry: A0A0H3GGJ2_KLEPH

LinkDB:  A0A0H3GGJ2_KLEPH 
Original site:  A0A0H3GGJ2_KLEPH

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (4)   
   InterPro (3)   
   Pfam (1)   
Literature (1)   
   PubMed (1)   
All databases (14)   

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ID   A0A0H3GGJ2_KLEPH        Unreviewed;       246 AA.
AC   A0A0H3GGJ2;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00040167, ECO:0000256|RuleBase:RU366031};
DE            EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109, ECO:0000256|RuleBase:RU366031};
GN   OrderedLocusNames=KPHS_01470 {ECO:0000313|EMBL:AEW58845.1};
OS   Klebsiella pneumoniae subsp. pneumoniae (strain HS11286).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=1125630 {ECO:0000313|EMBL:AEW58845.1, ECO:0000313|Proteomes:UP000007841};
RN   [1] {ECO:0000313|EMBL:AEW58845.1, ECO:0000313|Proteomes:UP000007841}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HS11286 {ECO:0000313|EMBL:AEW58845.1,
RC   ECO:0000313|Proteomes:UP000007841};
RX   PubMed=22408243; DOI=10.1128/JB.00043-12;
RA   Liu P., Li P., Jiang X., Bi D., Xie Y., Tai C., Deng Z., Rajakumar K.,
RA   Ou H.Y.;
RT   "Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae
RT   HS11286, a multidrug-resistant strain isolated from human sputum.";
RL   J. Bacteriol. 194:1841-1842(2012).
CC   -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC       hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC       {ECO:0000256|ARBA:ARBA00037589, ECO:0000256|RuleBase:RU366031}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC         Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC         ChEBI:CHEBI:57845; EC=4.2.1.75;
CC         Evidence={ECO:0000256|ARBA:ARBA00000783,
CC         ECO:0000256|RuleBase:RU366031};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC       {ECO:0000256|ARBA:ARBA00004772, ECO:0000256|RuleBase:RU366031}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000256|ARBA:ARBA00008133, ECO:0000256|RuleBase:RU366031}.
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DR   EMBL; CP003200; AEW58845.1; -; Genomic_DNA.
DR   RefSeq; WP_002883380.1; NC_016845.1.
DR   RefSeq; YP_005224447.1; NC_016845.1.
DR   AlphaFoldDB; A0A0H3GGJ2; -.
DR   STRING; 1125630.KPHS_01470; -.
DR   GeneID; 11845128; -.
DR   KEGG; kpm:KPHS_01470; -.
DR   PATRIC; fig|1125630.4.peg.146; -.
DR   HOGENOM; CLU_011276_9_4_6; -.
DR   UniPathway; UPA00251; UER00320.
DR   Proteomes; UP000007841; Chromosome.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR38042; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR38042:SF1; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366031};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW   ECO:0000256|RuleBase:RU366031};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007841}.
FT   DOMAIN          14..242
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
SQ   SEQUENCE   246 AA;  27577 MW;  C3BDCE64E974A118 CRC64;
     MSILVTRPLP QGEALVSRLR AMGRVAWSFP LIEFTPGREL PALGDALARL GPDDLLFALS
     QHAVEFAHAR LQQQGLPWPT SPRYFAIGRT TALALHTVSG QHIHYPLDRE ISEVLLQLPE
     LQNIAGKNAL ILRGNGGREL LGATLTERGA RVTFCECYQR SAKHYDGAEE AMRWQSRGVT
     TLVVTSGEML QQLWSLIPQW YREQWLLHCR VVVVSERLAL QARELGWQEI QVADSADNDA
     LLRALQ
//

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