ID   A0A0H3GL78_KLEPH        Unreviewed;      1293 AA.
AC   A0A0H3GL78;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=ATP-dependent serine activating enzyme {ECO:0000313|EMBL:AEW60138.1};
GN   OrderedLocusNames=KPHS_14400 {ECO:0000313|EMBL:AEW60138.1};
OS   Klebsiella pneumoniae subsp. pneumoniae (strain HS11286).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=1125630 {ECO:0000313|EMBL:AEW60138.1, ECO:0000313|Proteomes:UP000007841};
RN   [1] {ECO:0000313|EMBL:AEW60138.1, ECO:0000313|Proteomes:UP000007841}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HS11286 {ECO:0000313|EMBL:AEW60138.1,
RC   ECO:0000313|Proteomes:UP000007841};
RX   PubMed=22408243; DOI=10.1128/JB.00043-12;
RA   Liu P., Li P., Jiang X., Bi D., Xie Y., Tai C., Deng Z., Rajakumar K.,
RA   Ou H.Y.;
RT   "Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae
RT   HS11286, a multidrug-resistant strain isolated from human sputum.";
RL   J. Bacteriol. 194:1841-1842(2012).
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
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DR   EMBL; CP003200; AEW60138.1; -; Genomic_DNA.
DR   RefSeq; WP_004151663.1; NC_016845.1.
DR   RefSeq; YP_005225740.1; NC_016845.1.
DR   AlphaFoldDB; A0A0H3GL78; -.
DR   STRING; 1125630.KPHS_14400; -.
DR   GeneID; 11846441; -.
DR   KEGG; kpm:KPHS_14400; -.
DR   PATRIC; fig|1125630.4.peg.1400; -.
DR   HOGENOM; CLU_000022_2_13_6; -.
DR   Proteomes; UP000007841; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd17646; A_NRPS_AB3403-like; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF00668; Condensation; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007841}.
FT   DOMAIN          970..1045
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   1293 AA;  140945 MW;  DBD23632524FEE02 CRC64;
     MTTRLPLVAA QPGIWMAERL STLPGAWSVA HYVELRGALD PTLLGKAIVA GLQQADTLSL
     RFEEEEGEVW QWLAADRTFA EPSIIDLRTA PDPHRAATER MQADLAQDLR VDGGNPLVCH
     QLLRVGDDRW YWYQRYHHLL VDGFSFPAIT RQIAAIYRAW QRGEATPESP FTPFAEVVDE
     YQRYAGSEAW QRDKAFWQAQ RQALPAPASL SAAPLGGRAA GSDIWRMKLE MNADAFRRLA
     SHAPQCQPAD LALALTTLWL GRLCNRMDYA AGFIFMRRMG SAALTSTGPV LNVLPLAVHI
     DARETLADLA MRLAAQLKKM RRHQRYDAEQ IVRDSGKAAG DEPLFGPVLN VKVFDYQLDI
     DGVQAVTHTL ATGPVNDLEL ALFPDETGGL SLEILANKAR YDEAELRRHM ARLTALLAQF
     AADPTLRCGE AEMLSADELA RLAAVNDTAV PLPATTLSAL VADQARKTPD APALADARWQ
     FSYREMRQQV VALAQLLRQR GVKPGDSVAV ALPRSVFLTL ALHGIVEAGA AWLPLDTGYP
     DDRLRMMLED ARPSLLIATE DQLARFSDIP GLESLCYQQP LAAGDDAPLA LSKPDHTAYI
     IFTSGSTGRP KGVMVGQTAI VNRLLWMQDR YPLSADDVVA QKTPCSFDVS VWEFWWPFIA
     GAQLVMAEPE AHRDPQAMQQ FFARYGVTTT HFVPSMLAAF VASLDADSVA ACRTLRRVFC
     SGEALPTELC REWERLTGAP LHNLYGPTEA AVDVSWYPAC GPELAAVTGS SVPIGWPVWN
     TGLRILDAAM RPVPPGVAGD LYLTGIQLAQ GYLGRPDLTA SRFIADPFAP GERMYRTGDV
     ARWLANGAVE YLGRSDDQLK IRGQRIELGE IDRVMSALPD VGQAVSHACV FNQAAATGGD
     ARQLVGYLVS DSGLPLDTAA LKARLAEQLP PHMVPVVLMQ LAELPLSANG KLDRKALPLP
     TLGGERSGRP PEPGMETLVA AVFSQLLGCE VNDIDADFFA LGGHSLLAMR LAAQLSRQLA
     RQVTPGQVMV ASTVGKLSAL LAADLSDEQA RRLGLDTLLP LRESDGPTLF CFHPASGFAW
     QFSVLARYLS PRWSITGIQS PRPQGPMASA ASLDEVCEHH LQTLLAQQPH GPYYLFGYSL
     GGTLAQGIAA RLRQRGEAVA FLGLLDTWPP ETQNWAEKEA NGLDPEVLAE IDREREAFLA
     AQQGQASGEL FSAIEGNYAD AVRLLTTAHS AKFDGKATLF VAEKTRQEGM DPQVVWGPWV
     GELEVFSQNC AHVDIISPQA FEAIGPVVRE ILG
//