ID A0A0H3GLL0_KLEPH Unreviewed; 416 AA.
AC A0A0H3GLL0;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Lipid III flippase {ECO:0000256|HAMAP-Rule:MF_02024};
GN Name=wzxE {ECO:0000256|HAMAP-Rule:MF_02024};
GN OrderedLocusNames=KPHS_01390 {ECO:0000313|EMBL:AEW58837.1};
OS Klebsiella pneumoniae subsp. pneumoniae (strain HS11286).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=1125630 {ECO:0000313|EMBL:AEW58837.1, ECO:0000313|Proteomes:UP000007841};
RN [1] {ECO:0000313|EMBL:AEW58837.1, ECO:0000313|Proteomes:UP000007841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HS11286 {ECO:0000313|EMBL:AEW58837.1,
RC ECO:0000313|Proteomes:UP000007841};
RX PubMed=22408243; DOI=10.1128/JB.00043-12;
RA Liu P., Li P., Jiang X., Bi D., Xie Y., Tai C., Deng Z., Rajakumar K.,
RA Ou H.Y.;
RT "Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae
RT HS11286, a multidrug-resistant strain isolated from human sputum.";
RL J. Bacteriol. 194:1841-1842(2012).
CC -!- FUNCTION: Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA-
CC Fuc4NAc (lipid III) from the inner to the outer leaflet of the
CC cytoplasmic membrane during the assembly of enterobacterial common
CC antigen (ECA). {ECO:0000256|HAMAP-Rule:MF_02024}.
CC -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial common
CC antigen biosynthesis. {ECO:0000256|HAMAP-Rule:MF_02024}.
CC -!- SUBUNIT: Probably part of a complex composed of WzxE, WzyE and WzzE.
CC {ECO:0000256|HAMAP-Rule:MF_02024}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC Rule:MF_02024}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_02024}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass
CC membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polysaccharide transport (PST) (TC 2.A.66.2)
CC family. {ECO:0000256|HAMAP-Rule:MF_02024}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_02024}.
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DR EMBL; CP003200; AEW58837.1; -; Genomic_DNA.
DR RefSeq; WP_002883312.1; NC_016845.1.
DR RefSeq; YP_005224439.1; NC_016845.1.
DR AlphaFoldDB; A0A0H3GLL0; -.
DR STRING; 1125630.KPHS_01390; -.
DR GeneID; 11845120; -.
DR KEGG; kpm:KPHS_01390; -.
DR PATRIC; fig|1125630.4.peg.138; -.
DR HOGENOM; CLU_042154_0_0_6; -.
DR OMA; KFTIMAL; -.
DR UniPathway; UPA00566; -.
DR Proteomes; UP000007841; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd13125; MATE_like_10; 1.
DR HAMAP; MF_02024; WzxE; 1.
DR InterPro; IPR002797; Polysacc_synth.
DR InterPro; IPR044550; WzxE.
DR InterPro; IPR032896; WzxE_Proteobacteria.
DR PANTHER; PTHR30250:SF26; LIPID III FLIPPASE; 1.
DR PANTHER; PTHR30250; PST FAMILY PREDICTED COLANIC ACID TRANSPORTER; 1.
DR Pfam; PF01943; Polysacc_synt; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02024};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_02024};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02024};
KW Reference proteome {ECO:0000313|Proteomes:UP000007841};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_02024};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_02024}; Transport {ECO:0000256|HAMAP-Rule:MF_02024}.
FT TRANSMEM 45..67
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT TRANSMEM 79..105
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT TRANSMEM 117..138
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT TRANSMEM 217..238
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT TRANSMEM 264..285
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT TRANSMEM 297..314
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT TRANSMEM 334..355
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT TRANSMEM 394..412
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
SQ SEQUENCE 416 AA; 44639 MW; 61F62FB051F2030F CRC64;
MSLAKASLWT AASTLVKIGA GLLVVKLLAV SFGPAGVGQA GNFRQLVTVL GVLAGAGIFN
GVTKLVAQHH DDPPRLKQVV GTSSAMVLGF STLLALVFLL AAAPISQGLF GHTHYQGLVR
LVALVQMGIA WANFLLALMK GFRDAAGNAF SLIAGSLIGV AAYYACYVLG GYQGALLGLA
LVPALVVVPA GIMLWRRGNI PLSALRPRWD NGLAGQLSKF TLMALITSVT LPVAYVMMRN
LLAAHYGWEA VGIWQGVSSI SDAYLQFITA SFSVYLLPTL SRLSAKTDIT REIVKSLKFV
LPAVAAASLT VWLLRDFAIW LLFSDRFTAM RDLFAWQLVG DVLKVGAYVY GYLVIAKASL
RFYILTEISQ FALLTAFSHW LIPAHGAVGA AQAYMATYIV YFALCSGVFL LWRKRA
//