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Database: UniProt
Entry: A0A0H3GLL0_KLEPH
LinkDB: A0A0H3GLL0_KLEPH
Original site: A0A0H3GLL0_KLEPH 
ID   A0A0H3GLL0_KLEPH        Unreviewed;       416 AA.
AC   A0A0H3GLL0;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=Lipid III flippase {ECO:0000256|HAMAP-Rule:MF_02024};
GN   Name=wzxE {ECO:0000256|HAMAP-Rule:MF_02024};
GN   OrderedLocusNames=KPHS_01390 {ECO:0000313|EMBL:AEW58837.1};
OS   Klebsiella pneumoniae subsp. pneumoniae (strain HS11286).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=1125630 {ECO:0000313|EMBL:AEW58837.1, ECO:0000313|Proteomes:UP000007841};
RN   [1] {ECO:0000313|EMBL:AEW58837.1, ECO:0000313|Proteomes:UP000007841}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HS11286 {ECO:0000313|EMBL:AEW58837.1,
RC   ECO:0000313|Proteomes:UP000007841};
RX   PubMed=22408243; DOI=10.1128/JB.00043-12;
RA   Liu P., Li P., Jiang X., Bi D., Xie Y., Tai C., Deng Z., Rajakumar K.,
RA   Ou H.Y.;
RT   "Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae
RT   HS11286, a multidrug-resistant strain isolated from human sputum.";
RL   J. Bacteriol. 194:1841-1842(2012).
CC   -!- FUNCTION: Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA-
CC       Fuc4NAc (lipid III) from the inner to the outer leaflet of the
CC       cytoplasmic membrane during the assembly of enterobacterial common
CC       antigen (ECA). {ECO:0000256|HAMAP-Rule:MF_02024}.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial common
CC       antigen biosynthesis. {ECO:0000256|HAMAP-Rule:MF_02024}.
CC   -!- SUBUNIT: Probably part of a complex composed of WzxE, WzyE and WzzE.
CC       {ECO:0000256|HAMAP-Rule:MF_02024}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_02024}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_02024}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass
CC       membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the polysaccharide transport (PST) (TC 2.A.66.2)
CC       family. {ECO:0000256|HAMAP-Rule:MF_02024}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|HAMAP-Rule:MF_02024}.
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DR   EMBL; CP003200; AEW58837.1; -; Genomic_DNA.
DR   RefSeq; WP_002883312.1; NC_016845.1.
DR   RefSeq; YP_005224439.1; NC_016845.1.
DR   AlphaFoldDB; A0A0H3GLL0; -.
DR   STRING; 1125630.KPHS_01390; -.
DR   GeneID; 11845120; -.
DR   KEGG; kpm:KPHS_01390; -.
DR   PATRIC; fig|1125630.4.peg.138; -.
DR   HOGENOM; CLU_042154_0_0_6; -.
DR   OMA; KFTIMAL; -.
DR   UniPathway; UPA00566; -.
DR   Proteomes; UP000007841; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd13125; MATE_like_10; 1.
DR   HAMAP; MF_02024; WzxE; 1.
DR   InterPro; IPR002797; Polysacc_synth.
DR   InterPro; IPR044550; WzxE.
DR   InterPro; IPR032896; WzxE_Proteobacteria.
DR   PANTHER; PTHR30250:SF26; LIPID III FLIPPASE; 1.
DR   PANTHER; PTHR30250; PST FAMILY PREDICTED COLANIC ACID TRANSPORTER; 1.
DR   Pfam; PF01943; Polysacc_synt; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02024};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW   Rule:MF_02024};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02024};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007841};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW   Rule:MF_02024};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW   Rule:MF_02024}; Transport {ECO:0000256|HAMAP-Rule:MF_02024}.
FT   TRANSMEM        45..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT   TRANSMEM        79..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT   TRANSMEM        117..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT   TRANSMEM        217..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT   TRANSMEM        264..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT   TRANSMEM        297..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT   TRANSMEM        334..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
FT   TRANSMEM        394..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02024"
SQ   SEQUENCE   416 AA;  44639 MW;  61F62FB051F2030F CRC64;
     MSLAKASLWT AASTLVKIGA GLLVVKLLAV SFGPAGVGQA GNFRQLVTVL GVLAGAGIFN
     GVTKLVAQHH DDPPRLKQVV GTSSAMVLGF STLLALVFLL AAAPISQGLF GHTHYQGLVR
     LVALVQMGIA WANFLLALMK GFRDAAGNAF SLIAGSLIGV AAYYACYVLG GYQGALLGLA
     LVPALVVVPA GIMLWRRGNI PLSALRPRWD NGLAGQLSKF TLMALITSVT LPVAYVMMRN
     LLAAHYGWEA VGIWQGVSSI SDAYLQFITA SFSVYLLPTL SRLSAKTDIT REIVKSLKFV
     LPAVAAASLT VWLLRDFAIW LLFSDRFTAM RDLFAWQLVG DVLKVGAYVY GYLVIAKASL
     RFYILTEISQ FALLTAFSHW LIPAHGAVGA AQAYMATYIV YFALCSGVFL LWRKRA
//
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