ID A0A0H3GME5_KLEPH Unreviewed; 180 AA.
AC A0A0H3GME5;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Cell division protein ZapC {ECO:0000256|HAMAP-Rule:MF_00906, ECO:0000256|PIRNR:PIRNR010252};
GN Name=zapC {ECO:0000256|HAMAP-Rule:MF_00906};
GN OrderedLocusNames=KPHS_18550 {ECO:0000313|EMBL:AEW60553.1};
OS Klebsiella pneumoniae subsp. pneumoniae (strain HS11286).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=1125630 {ECO:0000313|EMBL:AEW60553.1, ECO:0000313|Proteomes:UP000007841};
RN [1] {ECO:0000313|EMBL:AEW60553.1, ECO:0000313|Proteomes:UP000007841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HS11286 {ECO:0000313|EMBL:AEW60553.1,
RC ECO:0000313|Proteomes:UP000007841};
RX PubMed=22408243; DOI=10.1128/JB.00043-12;
RA Liu P., Li P., Jiang X., Bi D., Xie Y., Tai C., Deng Z., Rajakumar K.,
RA Ou H.Y.;
RT "Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae
RT HS11286, a multidrug-resistant strain isolated from human sputum.";
RL J. Bacteriol. 194:1841-1842(2012).
CC -!- FUNCTION: Contributes to the efficiency of the cell division process by
CC stabilizing the polymeric form of the cell division protein FtsZ. Acts
CC by promoting interactions between FtsZ protofilaments and suppressing
CC the GTPase activity of FtsZ. {ECO:0000256|HAMAP-Rule:MF_00906,
CC ECO:0000256|PIRNR:PIRNR010252}.
CC -!- SUBUNIT: Interacts directly with FtsZ. {ECO:0000256|HAMAP-
CC Rule:MF_00906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00906,
CC ECO:0000256|PIRNR:PIRNR010252}.
CC -!- SIMILARITY: Belongs to the ZapC family. {ECO:0000256|HAMAP-
CC Rule:MF_00906, ECO:0000256|PIRNR:PIRNR010252}.
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DR EMBL; CP003200; AEW60553.1; -; Genomic_DNA.
DR RefSeq; WP_002898308.1; NC_016845.1.
DR RefSeq; YP_005226155.1; NC_016845.1.
DR AlphaFoldDB; A0A0H3GME5; -.
DR SMR; A0A0H3GME5; -.
DR STRING; 1125630.KPHS_18550; -.
DR GeneID; 11846870; -.
DR GeneID; 64296123; -.
DR KEGG; kpm:KPHS_18550; -.
DR PATRIC; fig|1125630.4.peg.1806; -.
DR HOGENOM; CLU_128248_0_0_6; -.
DR Proteomes; UP000007841; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00906; ZapC; 1.
DR InterPro; IPR009809; ZapC.
DR InterPro; IPR048372; ZapC_C.
DR InterPro; IPR048373; ZapC_N.
DR Pfam; PF07126; ZapC_C; 1.
DR Pfam; PF21083; ZapC_N; 1.
DR PIRSF; PIRSF010252; ZapC; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP-
KW Rule:MF_00906};
KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP-
KW Rule:MF_00906};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00906};
KW Reference proteome {ECO:0000313|Proteomes:UP000007841};
KW Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_00906}.
FT DOMAIN 3..89
FT /note="Cell-division protein ZapC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21083"
FT DOMAIN 90..170
FT /note="Cell-division protein ZapC C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07126"
SQ SEQUENCE 180 AA; 20399 MW; FB871D434604E1F7 CRC64;
MRIKPDDNWR WYYDEEHDRM MLDLANGMLF RSRFARRMLT PDAFAPSGFC VDDAALYFSF
EEKCRDLELS KEQRAELVLN ALTAIRFLKP QMPKSWHFIA HTHHWQPSGG DAACVWLSDT
GEQVNLLVVE PGDNAALCLL AQPGLTLAGR VMQLGDVIKI MNDRLQPAQS AVSYSLGQAV
//
