ID A0A0H3GMF8_KLEPH Unreviewed; 771 AA.
AC A0A0H3GMF8;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=LPS-assembly protein LptD {ECO:0000256|HAMAP-Rule:MF_01411};
GN Name=lptD {ECO:0000256|HAMAP-Rule:MF_01411};
GN OrderedLocusNames=KPHS_07630 {ECO:0000313|EMBL:AEW59461.1};
OS Klebsiella pneumoniae subsp. pneumoniae (strain HS11286).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=1125630 {ECO:0000313|EMBL:AEW59461.1, ECO:0000313|Proteomes:UP000007841};
RN [1] {ECO:0000313|EMBL:AEW59461.1, ECO:0000313|Proteomes:UP000007841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HS11286 {ECO:0000313|EMBL:AEW59461.1,
RC ECO:0000313|Proteomes:UP000007841};
RX PubMed=22408243; DOI=10.1128/JB.00043-12;
RA Liu P., Li P., Jiang X., Bi D., Xie Y., Tai C., Deng Z., Rajakumar K.,
RA Ou H.Y.;
RT "Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae
RT HS11286, a multidrug-resistant strain isolated from human sputum.";
RL J. Bacteriol. 194:1841-1842(2012).
CC -!- FUNCTION: Together with LptE, is involved in the assembly of
CC lipopolysaccharide (LPS) at the surface of the outer membrane.
CC {ECO:0000256|HAMAP-Rule:MF_01411}.
CC -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC complex. Interacts with LptE and LptA. {ECO:0000256|HAMAP-
CC Rule:MF_01411}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000256|HAMAP-
CC Rule:MF_01411}.
CC -!- SIMILARITY: Belongs to the LptD family. {ECO:0000256|HAMAP-
CC Rule:MF_01411}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_01411}.
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DR EMBL; CP003200; AEW59461.1; -; Genomic_DNA.
DR RefSeq; WP_004219845.1; NC_016845.1.
DR RefSeq; YP_005225063.1; NC_016845.1.
DR AlphaFoldDB; A0A0H3GMF8; -.
DR STRING; 1125630.KPHS_07630; -.
DR GeneID; 11845753; -.
DR KEGG; kpm:KPHS_07630; -.
DR PATRIC; fig|1125630.4.peg.742; -.
DR HOGENOM; CLU_009039_2_0_6; -.
DR Proteomes; UP000007841; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR Gene3D; 2.60.450.10; Lipopolysaccharide (LPS) transport protein A like domain; 1.
DR HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR InterPro; IPR020889; LipoPS_assembly_LptD.
DR InterPro; IPR007543; LptD_C.
DR InterPro; IPR005653; OstA-like_N.
DR PANTHER; PTHR30189; LPS-ASSEMBLY PROTEIN; 1.
DR PANTHER; PTHR30189:SF1; LPS-ASSEMBLY PROTEIN LPTD; 1.
DR Pfam; PF04453; LptD; 1.
DR Pfam; PF03968; LptD_N; 1.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|ARBA:ARBA00023237, ECO:0000256|HAMAP-
KW Rule:MF_01411};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01411};
KW Reference proteome {ECO:0000313|Proteomes:UP000007841};
KW Signal {ECO:0000256|HAMAP-Rule:MF_01411}.
FT DOMAIN 42..183
FT /note="Organic solvent tolerance-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03968"
FT DOMAIN 298..682
FT /note="LptD C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04453"
SQ SEQUENCE 771 AA; 87249 MW; 3F539D0494A1E57F CRC64;
MIASALYSQQ GLAADLATQC MLGVPSYDRP LVEGRPGDLP VTINADHAKG NYPDNAVFTG
NVDINQGNSR LRADEVQLHQ QQAAGQAQPV RTVDALGNVH YDDNQVILKG PKAWSNLNTK
DTNVWQGDYQ MVGRQGRGTA DLMKQRGENR YTILENGSFT SCLPGSDTWS VVGSEVIHDR
EEQVAEIWNA RFKLGSVPIF YSPYLQLPVG DKRRSGFLIP NAKYSTKNGV EFSLPYYWNI
APNFDATITP HYMNKRGGVM WENEFRYLTQ LGSGLTEFDY LPSDKVYEDD HSSDSNSRRW
LFYWNHSGVI DQVWRLNADY TKVSDPDYFN DFSSKYGSST DGYATQKFSA GYVNQNFDAT
VSTKQFQVFD RESSNSYSAE PQLDVNYYQN DVGPFDTHLY GQVAHFVNSN NNMPEATRVH
FEPTINLPLS NGWGSLNTEA KLLATHYQQS NLDKYNAANG TDYKESVSRV MPQFKVDGKM
VFERDLQEGF TQTLEPRVQY LYVPYRDQSE IGNYDSTLLQ SDYTGLFRDR TYSGLDRIAS
ANQVTTGLTS RVYDAAAVER FNISVGQIYY FTESRTGDDN INWENNDTTG SLVWAGDTYW
RIADEWGLRG GIQYDTRLDN VATGNGTIEY RRDENRLVQL NYRYASPEYI QATLPSYSTA
AQYKQGISQV GMTASWPIVD RWSVVGAYYY DTNTRKAANQ MLGVQYNSCC YAIRLGYERK
VNGWNSNDNG GESKYDNTFG INIELRGLSS NYGLGTQQML RSNILPYQSS L
//
