ID A0A0H3GNC1_KLEPH Unreviewed; 291 AA.
AC A0A0H3GNC1;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=6-phosphogluconate dehydrogenase {ECO:0000313|EMBL:AEW61325.1};
GN OrderedLocusNames=KPHS_26270 {ECO:0000313|EMBL:AEW61325.1};
OS Klebsiella pneumoniae subsp. pneumoniae (strain HS11286).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=1125630 {ECO:0000313|EMBL:AEW61325.1, ECO:0000313|Proteomes:UP000007841};
RN [1] {ECO:0000313|EMBL:AEW61325.1, ECO:0000313|Proteomes:UP000007841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HS11286 {ECO:0000313|EMBL:AEW61325.1,
RC ECO:0000313|Proteomes:UP000007841};
RX PubMed=22408243; DOI=10.1128/JB.00043-12;
RA Liu P., Li P., Jiang X., Bi D., Xie Y., Tai C., Deng Z., Rajakumar K.,
RA Ou H.Y.;
RT "Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae
RT HS11286, a multidrug-resistant strain isolated from human sputum.";
RL J. Bacteriol. 194:1841-1842(2012).
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DR EMBL; CP003200; AEW61325.1; -; Genomic_DNA.
DR RefSeq; WP_004199863.1; NC_016845.1.
DR RefSeq; YP_005226927.1; NC_016845.1.
DR AlphaFoldDB; A0A0H3GNC1; -.
DR STRING; 1125630.KPHS_26270; -.
DR GeneID; 11847645; -.
DR KEGG; kpm:KPHS_26270; -.
DR PATRIC; fig|1125630.4.peg.2554; -.
DR HOGENOM; CLU_035117_0_4_6; -.
DR Proteomes; UP000007841; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007841};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..291
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002610183"
FT DOMAIN 6..162
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 167..285
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 173
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 291 AA; 30652 MW; A663FF264B9828DD CRC64;
MSTLPKVAVL GLGAMGHAFA SNLLKNGFTV AGWNRSPARG EDLQAHGLSL HATPQQAVAD
AEVIISMLAD GEATLEVLAQ IAPASQPQAI YCQMGTIGLP ETRQAIALLR ELQPAMTYID
APVSGTKAPA EKAQILVLAS GDREKGAAAE PVFAAISRGT QWFGEAGNSQ KMKLVLNAWL
ISMMQGIAES AQLAKTLGFT PDQLWSALEG GPLAAPYVKV KLDAIASEQY TPQMQLAHAL
KDARLALSLA EPHTMPGLEN IAELWQQAAD AGYAGEDLSA VYQWLSPSSK A
//
