ID A0A0H3GT64_KLEPH Unreviewed; 417 AA.
AC A0A0H3GT64;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Nucleoside permease NupG {ECO:0000256|HAMAP-Rule:MF_02049};
GN Name=nupG {ECO:0000256|HAMAP-Rule:MF_02049};
GN OrderedLocusNames=KPHS_44670 {ECO:0000313|EMBL:AEW63165.1};
OS Klebsiella pneumoniae subsp. pneumoniae (strain HS11286).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=1125630 {ECO:0000313|EMBL:AEW63165.1, ECO:0000313|Proteomes:UP000007841};
RN [1] {ECO:0000313|EMBL:AEW63165.1, ECO:0000313|Proteomes:UP000007841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HS11286 {ECO:0000313|EMBL:AEW63165.1,
RC ECO:0000313|Proteomes:UP000007841};
RX PubMed=22408243; DOI=10.1128/JB.00043-12;
RA Liu P., Li P., Jiang X., Bi D., Xie Y., Tai C., Deng Z., Rajakumar K.,
RA Ou H.Y.;
RT "Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae
RT HS11286, a multidrug-resistant strain isolated from human sputum.";
RL J. Bacteriol. 194:1841-1842(2012).
CC -!- FUNCTION: Broad-specificity transporter of purine and pyrimidine
CC nucleosides. Transport is driven by a proton motive force.
CC {ECO:0000256|HAMAP-Rule:MF_02049}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC Rule:MF_02049}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_02049}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass
CC membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family.
CC {ECO:0000256|HAMAP-Rule:MF_02049}.
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DR EMBL; CP003200; AEW63165.1; -; Genomic_DNA.
DR RefSeq; WP_004151767.1; NC_016845.1.
DR RefSeq; YP_005228767.1; NC_016845.1.
DR AlphaFoldDB; A0A0H3GT64; -.
DR STRING; 1125630.KPHS_44670; -.
DR GeneID; 11849519; -.
DR KEGG; kpm:KPHS_44670; -.
DR PATRIC; fig|1125630.4.peg.4364; -.
DR HOGENOM; CLU_013133_1_2_6; -.
DR Proteomes; UP000007841; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015506; F:nucleoside:proton symporter activity; IEA:UniProtKB-UniRule.
DR CDD; cd06177; MFS_NHS; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR HAMAP; MF_02049; NupG; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004740; Nuc_H_symport.
DR InterPro; IPR033667; NupG.
DR NCBIfam; TIGR00889; 2A0110; 1.
DR PANTHER; PTHR23522; BLL5896 PROTEIN; 1.
DR PANTHER; PTHR23522:SF4; NUCLEOSIDE PERMEASE NUPG-RELATED; 1.
DR Pfam; PF03825; Nuc_H_symport; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02049};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_02049};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02049};
KW Reference proteome {ECO:0000313|Proteomes:UP000007841};
KW Symport {ECO:0000256|HAMAP-Rule:MF_02049};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_02049};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_02049}; Transport {ECO:0000256|HAMAP-Rule:MF_02049}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02049"
FT TRANSMEM 37..58
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02049"
FT TRANSMEM 70..89
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02049"
FT TRANSMEM 95..116
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02049"
FT TRANSMEM 137..155
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02049"
FT TRANSMEM 161..179
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02049"
FT TRANSMEM 211..235
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02049"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02049"
FT TRANSMEM 282..300
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02049"
FT TRANSMEM 306..327
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02049"
FT TRANSMEM 348..369
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02049"
FT TRANSMEM 381..402
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02049"
FT DOMAIN 209..417
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 417 AA; 46236 MW; D1A1C48A374CEB69 CRC64;
MNLKLQLKIL SFLQFCLWGS WLTTLGSYMF VTLKFDGAAI GAVYSSLGIA AVLMPTLLGI
VADKWISAKW VYAICHLVGA LTLYLAAQVT TPGEMFLVIL LNSLAYMPTL GLINTISYYR
LQSAGLDIVT DFPPIRIWGT IGFILAMWGV SFSGFELSHM QLYIGATLSV LLTLFTLTLP
HIPVANAQRN QSWAEMLGLN AFALFKNKRM AIFFIFSMML GAELQITNMF GNTFLHSFDK
DPLFAGSFIV EHASVLMSIS QISETLFILT IPFFLSRYGI KNVMLISIVA WMLRFGLFAF
GDPTPFGTVL LVLSMIVYGC AFDFFNISGS VFVEKEVRPE IRASAQGMFL MMTNGFGCIL
GGMVSGKVVE HFTVEGITDW QSVWLIFAGY SLVLAFAFVA LFKYKHVRQP TAAQQSV
//
