ID A0A0H3GVI6_KLEPH Unreviewed; 334 AA.
AC A0A0H3GVI6;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA polymerase III subunit delta' {ECO:0000256|ARBA:ARBA00014363};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN OrderedLocusNames=KPHS_19760 {ECO:0000313|EMBL:AEW60674.1};
OS Klebsiella pneumoniae subsp. pneumoniae (strain HS11286).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=1125630 {ECO:0000313|EMBL:AEW60674.1, ECO:0000313|Proteomes:UP000007841};
RN [1] {ECO:0000313|EMBL:AEW60674.1, ECO:0000313|Proteomes:UP000007841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HS11286 {ECO:0000313|EMBL:AEW60674.1,
RC ECO:0000313|Proteomes:UP000007841};
RX PubMed=22408243; DOI=10.1128/JB.00043-12;
RA Liu P., Li P., Jiang X., Bi D., Xie Y., Tai C., Deng Z., Rajakumar K.,
RA Ou H.Y.;
RT "Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae
RT HS11286, a multidrug-resistant strain isolated from human sputum.";
RL J. Bacteriol. 194:1841-1842(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; CP003200; AEW60674.1; -; Genomic_DNA.
DR RefSeq; WP_002900676.1; NC_016845.1.
DR RefSeq; YP_005226276.1; NC_016845.1.
DR AlphaFoldDB; A0A0H3GVI6; -.
DR STRING; 1125630.KPHS_19760; -.
DR GeneID; 11846994; -.
DR KEGG; kpm:KPHS_19760; -.
DR PATRIC; fig|1125630.4.peg.1926; -.
DR HOGENOM; CLU_006229_4_3_6; -.
DR Proteomes; UP000007841; Chromosome.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR004622; DNA_pol_HolB.
DR InterPro; IPR015199; DNA_pol_III_delta_C.
DR InterPro; IPR048731; HolB_lid-gammaproteobact.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00678; holB; 1.
DR PANTHER; PTHR11669:SF8; DNA POLYMERASE III SUBUNIT DELTA; 1.
DR PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR Pfam; PF13177; DNA_pol3_delta2; 1.
DR Pfam; PF09115; DNApol3-delta_C; 1.
DR Pfam; PF21500; HolB_lid; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000007841};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 167..206
FT /note="DNA polymerase III subunit delta' AAA+ ATPase lid"
FT /evidence="ECO:0000259|Pfam:PF21500"
FT DOMAIN 209..321
FT /note="DNA polymerase III delta subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09115"
SQ SEQUENCE 334 AA; 37124 MW; 2EE171EB8F31613D CRC64;
MKWYPWLRPS FEQLVGSYQA GRGHHALLLQ SLNGMGGEAL IYALCRFLMC RQPEGHKSCG
HCHSCQLMQA GTHPDYYALS PEKGKSALGI DAVRDVNEKL YEHARLGGAK VVWISDAALL
TDAAANALLK TLEEPPENTW FFLACEEPAR LLTTLRSRCR LHHLAPPSEP YALAWLEREV
SLPQESLLTA LRLCASAPAA ALELLQEPLW TARQQLCQAL AATLASGDWL ALLPILNHEQ
AAVRLHWLAS LLVDAQKRQQ GITLVSNPDV WPLLEQLAHS LPAARLQAIA HDVCTCREQL
LNVVGVNREL LLTERLLRWE HYLQPGTGLP VSHL
//
