ID A0A0H3GVP9_KLEPH Unreviewed; 323 AA.
AC A0A0H3GVP9;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=diguanylate cyclase {ECO:0000256|ARBA:ARBA00012528};
DE EC=2.7.7.65 {ECO:0000256|ARBA:ARBA00012528};
GN OrderedLocusNames=KPHS_35080 {ECO:0000313|EMBL:AEW62206.1};
OS Klebsiella pneumoniae subsp. pneumoniae (strain HS11286).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=1125630 {ECO:0000313|EMBL:AEW62206.1, ECO:0000313|Proteomes:UP000007841};
RN [1] {ECO:0000313|EMBL:AEW62206.1, ECO:0000313|Proteomes:UP000007841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HS11286 {ECO:0000313|EMBL:AEW62206.1,
RC ECO:0000313|Proteomes:UP000007841};
RX PubMed=22408243; DOI=10.1128/JB.00043-12;
RA Liu P., Li P., Jiang X., Bi D., Xie Y., Tai C., Deng Z., Rajakumar K.,
RA Ou H.Y.;
RT "Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae
RT HS11286, a multidrug-resistant strain isolated from human sputum.";
RL J. Bacteriol. 194:1841-1842(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 GTP = 3',3'-c-di-GMP + 2 diphosphate; Xref=Rhea:RHEA:24898,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:58805; EC=2.7.7.65;
CC Evidence={ECO:0000256|ARBA:ARBA00034247};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Purine metabolism; 3',5'-cyclic di-GMP biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004665}.
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DR EMBL; CP003200; AEW62206.1; -; Genomic_DNA.
DR RefSeq; WP_002911798.1; NC_016845.1.
DR RefSeq; YP_005227808.1; NC_016845.1.
DR AlphaFoldDB; A0A0H3GVP9; -.
DR SMR; A0A0H3GVP9; -.
DR STRING; 1125630.KPHS_35080; -.
DR GeneID; 11848539; -.
DR KEGG; kpm:KPHS_35080; -.
DR PATRIC; fig|1125630.4.peg.3418; -.
DR HOGENOM; CLU_000445_11_32_6; -.
DR Proteomes; UP000007841; Chromosome.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR45138:SF9; DIGUANYLATE CYCLASE DGCM-RELATED; 1.
DR PANTHER; PTHR45138; REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF00990; GGDEF; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007841}.
FT DOMAIN 194..323
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
SQ SEQUENCE 323 AA; 36291 MW; E5158B34E4D2D455 CRC64;
MKLAGLHPDE QRRLQSLRSS GLLNSGKEER FDRLTRLARS LYNLPVASIS LVGEDLLHIK
SCAGLDVDTV PRDISFCAHT ILQTDPLIVN DMQQDERFHD NPLVIEAPFI RFYAGYPVQL
PDGATVGSFC LMDHQPRSFS AHEMQILSDL AAIVEDEFKV LDAATSDELT GLFNRRGFLT
LAEYALLTAQ RRHEPVSLAF VDLDRFKHIN DTWGHEEGDR ALIAIADLMK AAFRESDILA
RQGGDEFIIL FANTSRHDAA TAMETLSHNV ARFNQQAANP WQLAFSWGCV EYDPASHPSL
NALVATADRL MYQAKQKQGR ERR
//
