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Database: UniProt
Entry: A0A0H3H1C0_KLEPH
LinkDB: A0A0H3H1C0_KLEPH
Original site: A0A0H3H1C0_KLEPH 
ID   A0A0H3H1C0_KLEPH        Unreviewed;      1752 AA.
AC   A0A0H3H1C0;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   07-OCT-2020, entry version 25.
DE   SubName: Full=Conjugal transfer nickase/helicase TraI {ECO:0000313|EMBL:AEW92120.1};
GN   OrderedLocusNames=KPHS_p200710 {ECO:0000313|EMBL:AEW92120.1};
OS   Klebsiella pneumoniae subsp. pneumoniae (strain HS11286).
OG   Plasmid pKPHS2 {ECO:0000313|EMBL:AEW92120.1,
OG   ECO:0000313|Proteomes:UP000007841}.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=1125630 {ECO:0000313|EMBL:AEW92120.1, ECO:0000313|Proteomes:UP000007841};
RN   [1] {ECO:0000313|Proteomes:UP000007841}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HS11286 {ECO:0000313|Proteomes:UP000007841};
RC   PLASMID=pKPHS2 {ECO:0000313|Proteomes:UP000007841};
RX   PubMed=22408243; DOI=10.1128/JB.00043-12;
RA   Liu P., Li P., Jiang X., Bi D., Xie Y., Tai C., Deng Z., Rajakumar K.,
RA   Ou H.Y.;
RT   "Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae
RT   HS11286, a multidrug-resistant strain isolated from human sputum.";
RL   J. Bacteriol. 194:1841-1842(2012).
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DR   EMBL; CP003224; AEW92120.1; -; Genomic_DNA.
DR   RefSeq; WP_014343483.1; NC_016846.1.
DR   RefSeq; YP_005229687.1; NC_016846.1.
DR   EnsemblBacteria; AEW92120; AEW92120; KPHS_p200710.
DR   GeneID; 11844884; -.
DR   KEGG; kpm:KPHS_p200710; -.
DR   PATRIC; fig|1125630.4.peg.5365; -.
DR   HOGENOM; CLU_001748_2_1_6; -.
DR   Proteomes; UP000007841; Plasmid pKPHS2.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0000746; P:conjugation; IEA:InterPro.
DR   InterPro; IPR014059; Conjug_relaxase_N.
DR   InterPro; IPR014129; Conjug_relaxase_TraI.
DR   InterPro; IPR009767; DNA_helicase_TraI.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR040668; TraI_2B.
DR   InterPro; IPR040987; TraI_N.
DR   InterPro; IPR014862; TrwC.
DR   Pfam; PF18272; ssDNA_TraI_N; 1.
DR   Pfam; PF07057; TraI; 1.
DR   Pfam; PF18340; TraI_2B; 1.
DR   Pfam; PF08751; TrwC; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR02686; relax_trwC; 1.
DR   TIGRFAMs; TIGR02760; TraI_TIGR; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000313|EMBL:AEW92120.1};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000313|EMBL:AEW92120.1};
KW   Hydrolase {ECO:0000313|EMBL:AEW92120.1};
KW   Nucleotide-binding {ECO:0000313|EMBL:AEW92120.1};
KW   Plasmid {ECO:0000313|EMBL:AEW92120.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007841}.
FT   DOMAIN          10..283
FT                   /note="TrwC"
FT                   /evidence="ECO:0000259|Pfam:PF08751"
FT   DOMAIN          576..628
FT                   /note="ssDNA_TraI_N"
FT                   /evidence="ECO:0000259|Pfam:PF18272"
FT   DOMAIN          634..713
FT                   /note="TraI_2B"
FT                   /evidence="ECO:0000259|Pfam:PF18340"
FT   DOMAIN          1432..1553
FT                   /note="TraI"
FT                   /evidence="ECO:0000259|Pfam:PF07057"
FT   REGION          1692..1714
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1228..1248
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1648..1675
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1692..1710
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1752 AA;  190459 MW;  6FEE8E6713B2012E CRC64;
     MLSFSQVKSA GSAGNYYTEK DNYYVIGSME ERWQGKGAEL LGLEGKVDKQ VFTELLQGKL
     PDGSDLTRIQ DGVNKHRPGY DLTFSAPKSV SMLAMLGGDK RLIDAHNRAV TVALNQVESL
     ASTRVKKDGV SETVLTGNLI IARFNHDTSR AQDPQIHTHS VVINATQNGD KWQTLASDTV
     GKTGFSETIL ANRIAFGKIY QNSLRADVES MGYKTVDAGR NGMWEMEGVP VESFSTRSQE
     LREAAGPDAS LKSRDVAALD TRKSKEAIDP AEKMVEWMNT LKETGFDIRG YREATDARAA
     ELARAPAAPV NTDGPDITDV VTKAIAGLSD RKVQFTYADL LARTVGQLEA KDGVFELARK
     GINAAIEREQ LIPLDREKGL FTSNIHVLDE LAVKALSQEV QRQNHVSVTP DASVVRQVTF
     SDAVSVLAQD RPVMGIVSGQ GGATGQRERV AELTLMAREQ GRDVHILAAD NRSRDFLAGD
     VRLAGETVTG KSALQDGTAF IPGGTLIVDQ AEKLSLKETI SLLDGAMRHN VQVLLSDSGK
     RSGTGSALTV LKDSGVNTYR WQGGHQTTAD IISEPDKGAR YSRLAQEFAV SVREGQESVA
     QISGTREQSV LNGLIRDSLR QEGVLGEKDT TITALTPVWL DSKSRGVRDY YREGMVMERW
     DPETRTHDRF VIDRVTASSN MLTLKDREGD RLDLKVSAVD SQWTLFRADT LPVAEGERLA
     VLGKIPDTRL KGGESVTVMK VEDGQLTVQR PGQKTTQTLA VGAGVFDGIK VGHGWVESPG
     RSVSETATVF ASVTQRELDN ATLNQLAQSG SHLRLYSAQD AARTTEKLSR HTAFSVVSEQ
     LKSRSGETDL DAAIAQQKAG LHTPAEQAIH LAIPLLESQD LTFSRPQLLA TAMETGGGKV
     SMADIDTTIQ AQIRSGQLLN VPVAPGRGND LLISRQAWDA EKSILTRVLE GKDAVAPLMD
     RVPASLMTDL TAGQRASTRM ILETPDRFTV VQGYAGVGKT TQFRAVMSAI SLLPEETRPH
     VIGLGPTHRA VGEMQSAGVD ARTTASFLHD TQLLQRNGQT PDFSNTLFLL DESSMVGLSD
     TAKALSLIAA GGGRAVLSGD TDQLQSISPG QPFRLMQQRS AADVAIMKEI VRQVPELRPA
     VYSLIERDLH RALTTIEQVT PEQVPRKEGA WAPGSSVVEF TPKQEKAIEK ALSEGKTLPE
     GQPATLYEAL VKDYTGRTPE AQSQTLVITH LNKDRRALNS LIHDARRENG ETGKEEITLP
     VLVTSNIRDG ELRKLSTWTA HKEAVALVDN VYHRISKVDK DNQLITLTDS EGKERFISPR
     EASAEGVTLY RQEKITVSQG DRMRFSKSDP ERGYVANSIW EVQSVSGDSV TLSDGKITRT
     LTPKAEQAQQ HIDLAYAITA HGAQGASEPY AIALEGVAGG REQMASFESA YVALSRMKQH
     VQVYTDSREG WIKAIKNSPE KATAHDILEP RNDRAVKTAD LLFGRARPLD ETAAGRAALQ
     QSGLAQGSSP GKFISPGKKY PQPHVALPAF DKNGKAAGIW LSPLTDRDGR LEAIGGEGRI
     MGNEDARFVA LQNSRNGESL LAGNMGEGVR MARDNPDTGV VVRLAGDDRP WNPGAMTGGR
     VWAEPAPVAP VPQAGADIIL PPEVLAQRAA EEQQRREMEK QAEQTAREVA GEARKAGEPA
     DRVKEVIGDV IRGLERDRPG TEKTTLPDDP QFRRQEAAIQ QVASERLQRE RLQAVERDMV
     RDLNREKTLG GD
//
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