ID A0A0H3J848_CLOPA Unreviewed; 653 AA.
AC A0A0H3J848;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=DNA polymerase {ECO:0000313|EMBL:AJA54069.1, ECO:0000313|EMBL:KRU13906.1};
DE EC=2.7.7.7 {ECO:0000313|EMBL:AJA54069.1};
GN ORFNames=CLPA_c40520 {ECO:0000313|EMBL:AJA54069.1}, CP6013_03162
GN {ECO:0000313|EMBL:KRU13906.1};
OS Clostridium pasteurianum DSM 525 = ATCC 6013.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262449 {ECO:0000313|EMBL:AJA54069.1, ECO:0000313|Proteomes:UP000030905};
RN [1] {ECO:0000313|EMBL:AJA54069.1, ECO:0000313|Proteomes:UP000030905}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 525 {ECO:0000313|EMBL:AJA54069.1}, and DSM 525 / ATCC 6013
RC {ECO:0000313|Proteomes:UP000030905};
RX PubMed=25700415;
RA Poehlein A., Grosse-Honebrink A., Zhang Y., Minton N.P., Daniel R.;
RT "Complete Genome Sequence of the Nitrogen-Fixing and Solvent-Producing
RT Clostridium pasteurianum DSM 525.";
RL Genome Announc. 3:e01591-e01514(2015).
RN [2] {ECO:0000313|EMBL:KRU13906.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 6013 {ECO:0000313|EMBL:KRU13906.1};
RA Pyne M.E., Utturkar S.M., Brown S.D., Moo-Young M., Chung D.A., Chou P.C.;
RT "Improved Draft Genome Sequence of Clostridium pasteurianum Strain ATCC
RT 6013 (DSM 525) Using a Hybrid Next-Generation Sequencing Approach.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KRU13906.1, ECO:0000313|Proteomes:UP000028042}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6013 {ECO:0000313|EMBL:KRU13906.1,
RC ECO:0000313|Proteomes:UP000028042};
RX PubMed=25103768;
RA Pyne M.E., Utturkar S., Brown S.D., Moo-Young M., Chung D.A., Chou C.P.;
RT "Improved Draft Genome Sequence of Clostridium pasteurianum Strain ATCC
RT 6013 (DSM 525) Using a Hybrid Next-Generation Sequencing Approach.";
RL Genome Announc. 2:0-0(0).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
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DR EMBL; CP009268; AJA54069.1; -; Genomic_DNA.
DR EMBL; JPGY02000001; KRU13906.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0H3J848; -.
DR KEGG; cpae:CPAST_c40520; -.
DR KEGG; cpat:CLPA_c40520; -.
DR PATRIC; fig|1262449.7.peg.4081; -.
DR eggNOG; COG0749; Bacteria.
DR Proteomes; UP000028042; Unassembled WGS sequence.
DR Proteomes; UP000030905; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd08642; DNA_pol_A_pol_I_A; 1.
DR Gene3D; 3.30.70.370; -; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW DNA-directed DNA polymerase {ECO:0000313|EMBL:KRU13906.1};
KW Nucleotidyltransferase {ECO:0000313|EMBL:AJA54069.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030905};
KW Transferase {ECO:0000313|EMBL:AJA54069.1}.
FT DOMAIN 372..618
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 653 AA; 74712 MW; D0A4D669CE7BA60B CRC64;
MMDTLAIDVE TYSDLDIKNV GAYKYCESPA FEIMLFAYAF NDEPVQLVDL MSGEDLPDRV
IEALENPDII KTAFNANFER NAISNDFILI NCLPEQWQCT MVKAYTMGLP GSLDMVGKAM
HFPEDKQKMK EGKALIQYFC KPCKPTKSNG GRTRNLPEHA PEKWETFKLY CKQDVEVERG
IRNKLSRYKT LDKEQKLWEL DQKINDRGVG TDLVLIEKAI ECDTKYTEKL KIEAIELTGL
RNPNSAAQLK KWIGDRVGHE ITSLTKDSIP GLLEESNDEK VKRILELRQL MAKTSIKKYE
TMQRARCKDG RAHGLLQFYG ANRTGRWAGR LVQVQNLPQN HLPDLDDARN CIREGRFDDV
EFLYDSIPDT LSQLIRTAFV PREGNRFMVA DFSAIEARVI AWLAGEQWRL EVFKTHGKIY
EASASQMFKV PIDSIKKGSD LRQKGKIAEL ALGYGGSVGA LTSMDKKKSI PEEELPELVR
HWRNANTHIT TFWWDCDKAA KKAIKERTTV TLQHGIKFIY DPGVLFIQLP SGRRLSYIRP
KIEPHEKFSG DKITYEGMEQ TSKQWKRIDT YGPKLVENIV QATARDCLAE AMFKVEKAGY
PIVMHVHDEI IMDVPKDYGA IEEVNKIFGE PIDWAPGLPL KADGYECSYY MKD
//
