ID CNTC_STAAM Reviewed; 289 AA.
AC A0A0H3JU73;
DT 05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Metal-staphylopine import system permease protein CntC {ECO:0000305};
GN Name=cntC {ECO:0000303|PubMed:27230378};
GN OrderedLocusNames=SAV2465 {ECO:0000312|EMBL:BAB58627.1};
OS Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158878;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu50 / ATCC 700699;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
RN [2]
RP FUNCTION, SUBUNIT, INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=Mu50 / ATCC 700699;
RX PubMed=27230378; DOI=10.1126/science.aaf1018;
RA Ghssein G., Brutesco C., Ouerdane L., Fojcik C., Izaute A., Wang S.,
RA Hajjar C., Lobinski R., Lemaire D., Richaud P., Voulhoux R., Espaillat A.,
RA Cava F., Pignol D., Borezee-Durant E., Arnoux P.;
RT "Biosynthesis of a broad-spectrum nicotianamine-like metallophore in
RT Staphylococcus aureus.";
RL Science 352:1105-1109(2016).
CC -!- FUNCTION: Part of the ABC transporter complex CntABCDF (Opp1) involved
CC in the uptake of metal in complex with the metallophore staphylopine
CC (StP). May be involved in the import of a large array of divalent
CC metals ions such as nickel, cobalt, zinc, copper and iron. Probably
CC responsible for the translocation of the substrate across the membrane.
CC {ECO:0000269|PubMed:27230378}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (CntD and
CC CntF), two transmembrane proteins (CntB and CntC) and a solute-binding
CC protein (CntA). {ECO:0000305|PubMed:27230378}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Up-regulated in metal-poor media.
CC {ECO:0000269|PubMed:27230378}.
CC -!- DISRUPTION PHENOTYPE: Deletion of the cntABCDF genes decreases StP
CC intracellular levels and decreases the import of iron, zinc, nickel and
CC cobalt. {ECO:0000269|PubMed:27230378}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000305}.
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DR EMBL; BA000017; BAB58627.1; -; Genomic_DNA.
DR RefSeq; WP_000584759.1; NC_002758.2.
DR AlphaFoldDB; A0A0H3JU73; -.
DR KEGG; sav:SAV2465; -.
DR HOGENOM; CLU_028518_1_1_9; -.
DR PhylomeDB; A0A0H3JU73; -.
DR Proteomes; UP000002481; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006824; P:cobalt ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006826; P:iron ion transport; IEA:UniProtKB-KW.
DR GO; GO:0015675; P:nickel cation transport; IEA:UniProtKB-KW.
DR GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; MetI-like; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR InterPro; IPR025966; OppC_N.
DR PANTHER; PTHR43386; OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC; 1.
DR PANTHER; PTHR43386:SF1; OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC; 1.
DR Pfam; PF00528; BPD_transp_1; 1.
DR Pfam; PF12911; OppC_N; 1.
DR SUPFAM; SSF161098; MetI-like; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cobalt; Cobalt transport; Copper; Copper transport;
KW Ion transport; Iron; Iron transport; Membrane; Nickel; Nickel transport;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..289
FT /note="Metal-staphylopine import system permease protein
FT CntC"
FT /id="PRO_0000447274"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 73..262
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 289 AA; 31947 MW; 10D62A7123FA139A CRC64;
MIILKRLLQD KGAVIALGII VLYVFLGLAA PLVTFYDPNH IDTANKFAGI SFQHLLGTDH
LGRDILTRLI YAIRPSLLYV FVALFVSVLI GSILGFLSGY FQGFVDALIM RACDVMLAFP
SYVVTLALIA LFGMGAENII MAFILTRWAW FCRVIRTSVM QYTASDHVRF AKTIGMNDMK
IIHKHIMPLT LADIAIISSS SMCSMILQIS GFSFLGLGVK APTAEWGMML NEARKVMFTH
PEMMFAPGIA IVIIVMAFNF LSDALQIAID PRISSKDKLR SVKKGVVQS
//
