ID A0A0H3KKG6_BURM1 Unreviewed; 433 AA.
AC A0A0H3KKG6;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003370};
GN Name=gltA {ECO:0000313|EMBL:BAG45729.1};
GN OrderedLocusNames=BMULJ_03869 {ECO:0000313|EMBL:BAG45729.1};
OS Burkholderia multivorans (strain ATCC 17616 / 249).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=395019 {ECO:0000313|EMBL:BAG45729.1, ECO:0000313|Proteomes:UP000008815};
RN [1] {ECO:0000313|EMBL:BAG45729.1, ECO:0000313|Proteomes:UP000008815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17616 / 249 {ECO:0000313|Proteomes:UP000008815};
RA Ohtsubo Y., Yamashita A., Kurokawa K., Takami H., Yuhara S., Nishiyama E.,
RA Endo R., Miyazaki R., Ono A., Yano K., Ito M., Sota M., Yuji N.,
RA Hattori M., Tsuda M.;
RT "Complete genome sequence of Burkholderia multivorans ATCC 17616.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308,
CC ECO:0000256|RuleBase:RU003370};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC from oxaloacetate: step 1/2. {ECO:0000256|ARBA:ARBA00004751,
CC ECO:0000256|RuleBase:RU003370}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC ECO:0000256|RuleBase:RU003406}.
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DR EMBL; AP009386; BAG45729.1; -; Genomic_DNA.
DR RefSeq; WP_006399550.1; NC_010805.1.
DR AlphaFoldDB; A0A0H3KKG6; -.
DR STRING; 395019.BMULJ_03869; -.
DR GeneID; 66529718; -.
DR KEGG; bmj:BMULJ_03869; -.
DR eggNOG; COG0372; Bacteria.
DR HOGENOM; CLU_025068_0_0_4; -.
DR UniPathway; UPA00223; UER00717.
DR Proteomes; UP000008815; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd06114; EcCS_like; 1.
DR Gene3D; 2.20.28.60; -; 1.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR InterPro; IPR010953; Citrate_synthase_typ-I.
DR NCBIfam; TIGR01798; cit_synth_I; 1.
DR PANTHER; PTHR42871; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR42871:SF1; CITRATE SYNTHASE; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:BAG45729.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008815};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369};
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532,
KW ECO:0000256|RuleBase:RU003370}.
FT ACT_SITE 310
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 368
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 433 AA; 48530 MW; 850E3821FA7229FD CRC64;
MTPSDVKATL SFSDNSPSVE LPIYKGTMGP DVIDIRKLYG QTGKFTYDPG FMSTASCNSA
ITYIDGDKGE LLYRGYPIDN LAQNADFLET CYLLLKGELP NAAQKKEFVD TVTKHTMVHE
QMHFFFRGFR RDAHPMAILV AAVGALSAFY HDSLDINDPR HREVSAIRMI AKLPTLVAMA
YKYSIGQPFV YPKNDLSYSA NFMRMMFSNP CEEYQVNDVL VRALDRILIL HADHEQNAST
STVRLAGSSG ANPFACIAAG IACLWGPAHG GANEAALNML EQIGTPENIP EFIKQVKDKN
SGVKLMGFGH RVYKNYDPRA KLMRETCYEV LNELGLHDDP LFKLAMQLEK IALEDEYFVS
RKLYPNVDFY SGIVQRALGI PTSMFTCIFA MARTVGWIAQ WNEMIADPEQ KIGRPRQLFI
GDTPREAKPL NAR
//
