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Database: UniProt
Entry: A0A0H3XL82_9MOLU
LinkDB: A0A0H3XL82_9MOLU
Original site: A0A0H3XL82_9MOLU 
ID   A0A0H3XL82_9MOLU        Unreviewed;       308 AA.
AC   A0A0H3XL82;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   22-APR-2020, entry version 22.
DE   RecName: Full=Probable endonuclease 4 {ECO:0000256|HAMAP-Rule:MF_00152};
DE            EC=3.1.21.2 {ECO:0000256|HAMAP-Rule:MF_00152};
DE   AltName: Full=Endodeoxyribonuclease IV {ECO:0000256|HAMAP-Rule:MF_00152};
DE   AltName: Full=Endonuclease IV {ECO:0000256|HAMAP-Rule:MF_00152};
GN   Name=nfo {ECO:0000256|HAMAP-Rule:MF_00152,
GN   ECO:0000313|EMBL:AKM54239.1};
GN   ORFNames=SERIO_v1c06710 {ECO:0000313|EMBL:AKM54239.1};
OS   Spiroplasma eriocheiris.
OC   Bacteria; Tenericutes; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC   Spiroplasma.
OX   NCBI_TaxID=315358 {ECO:0000313|EMBL:AKM54239.1, ECO:0000313|Proteomes:UP000035661};
RN   [1] {ECO:0000313|EMBL:AKM54239.1, ECO:0000313|Proteomes:UP000035661}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TDA-040725-5 {ECO:0000313|Proteomes:UP000035661};
RX   PubMed=26254485; DOI=10.1093/gbe/evv160;
RA   Lo W.S., Gasparich G.E., Kuo C.H.;
RT   "Found and Lost: The Fates of Horizontally Acquired Genes in Arthropod-
RT   Symbiotic Spiroplasma.";
RL   Genome Biol. Evol. 7:2458-2472(2015).
RN   [2] {ECO:0000313|Proteomes:UP000035661}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TDA-040725-5 {ECO:0000313|Proteomes:UP000035661};
RA   Lo W.-S., Kuo C.-H.;
RT   "Complete genome sequence of Spiroplasma eriocheiris TDA-040725-5 (DSM
RT   21848).";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endonuclease IV plays a role in DNA repair. It cleaves
CC       phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating
CC       a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
CC       {ECO:0000256|HAMAP-Rule:MF_00152}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphooligonucleotide end-
CC         products.; EC=3.1.21.2; Evidence={ECO:0000256|HAMAP-Rule:MF_00152};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00152};
CC       Note=Binds 3 Zn(2+) ions. {ECO:0000256|HAMAP-Rule:MF_00152};
CC   -!- SIMILARITY: Belongs to the AP endonuclease 2 family.
CC       {ECO:0000256|HAMAP-Rule:MF_00152, ECO:0000256|SAAS:SAAS01083619}.
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DR   EMBL; CP011856; AKM54239.1; -; Genomic_DNA.
DR   RefSeq; WP_047791466.1; NZ_CP011856.1.
DR   EnsemblBacteria; AKM54239; AKM54239; SERIO_v1c06710.
DR   KEGG; seri:SERIO_v1c06710; -.
DR   PATRIC; fig|743698.3.peg.673; -.
DR   KO; K01151; -.
DR   OrthoDB; 1088517at2; -.
DR   Proteomes; UP000035661; Chromosome.
DR   GO; GO:0008833; F:deoxyribonuclease IV (phage-T4-induced) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   CDD; cd00019; AP2Ec; 1.
DR   HAMAP; MF_00152; Nfo; 1.
DR   InterPro; IPR001719; AP_endonuc_2.
DR   InterPro; IPR018246; AP_endonuc_F2_Zn_BS.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   PANTHER; PTHR21445; PTHR21445; 1.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   SMART; SM00518; AP2Ec; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00587; nfo; 1.
DR   PROSITE; PS00729; AP_NUCLEASE_F2_1; 1.
DR   PROSITE; PS00731; AP_NUCLEASE_F2_3; 1.
DR   PROSITE; PS51432; AP_NUCLEASE_F2_4; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_00152,
KW   ECO:0000256|SAAS:SAAS01083620};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_00152,
KW   ECO:0000256|SAAS:SAAS01083629};
KW   Endonuclease {ECO:0000256|HAMAP-Rule:MF_00152,
KW   ECO:0000256|SAAS:SAAS01083624, ECO:0000313|EMBL:AKM54239.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00152, ECO:0000256|SAAS:SAAS01083627};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00152,
KW   ECO:0000256|SAAS:SAAS01083611};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00152, ECO:0000256|SAAS:SAAS01083625};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035661};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00152, ECO:0000256|SAAS:SAAS01083609}.
FT   DOMAIN          31..243
FT                   /note="AP_endonuc_2"
FT                   /evidence="ECO:0000259|Pfam:PF01261"
FT   METAL           76
FT                   /note="Zinc 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00152"
FT   METAL           117
FT                   /note="Zinc 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00152"
FT   METAL           152
FT                   /note="Zinc 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00152"
FT   METAL           152
FT                   /note="Zinc 2"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00152"
FT   METAL           186
FT                   /note="Zinc 2"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00152"
FT   METAL           189
FT                   /note="Zinc 3"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00152"
FT   METAL           221
FT                   /note="Zinc 2"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00152"
FT   METAL           234
FT                   /note="Zinc 3"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00152"
FT   METAL           236
FT                   /note="Zinc 3"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00152"
FT   METAL           266
FT                   /note="Zinc 2"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00152"
SQ   SEQUENCE   308 AA;  34838 MW;  2EB55B8EE4DE5A18 CRC64;
     MKDYNLIIGS HVSMNKQDNY LLGALNESLN NGANALMIYT GPPQNTIRVD VKNFFISEFH
     QQLAANNLSI DNVIIHAPYI INLANSFKKE TFEIAVEFLK KEIARADEIG IKTIVLHPGS
     AVGAEEQVGL DRIVEGLNLV LTAEQKALVA LETMAGKGSE LGVNFTQLKY IIDNVKLKDK
     LGVCWDTCHL HDSGYQLGEH LDSIIEEFDQ MIGLDRLLCL HINDSKNPLN AHKDRHENIG
     YGYLGFDNLL KIIYHPRLNN MVKILETPYV KDQDGKMHSP YQEEITMIKT KKFTDPFQKY
     GKTPIEKR
//
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