ID A0A0H4C250_9ACTN Unreviewed; 173 AA.
AC A0A0H4C250;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Glutamate--cysteine ligase {ECO:0008006|Google:ProtNLM};
GN ORFNames=QR97_14845 {ECO:0000313|EMBL:AKN70920.1};
OS Streptomyces sp. PBH53.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1577075 {ECO:0000313|EMBL:AKN70920.1, ECO:0000313|Proteomes:UP000036399};
RN [1] {ECO:0000313|EMBL:AKN70920.1, ECO:0000313|Proteomes:UP000036399}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PBH53 {ECO:0000313|EMBL:AKN70920.1,
RC ECO:0000313|Proteomes:UP000036399};
RX PubMed=26227608;
RA Gosse J.T., Hill P., Dowd S.E., Boddy C.N.;
RT "Draft Genome Sequence of Streptomyces sp. Strain PBH53, Isolated from an
RT Urban Environment.";
RL Genome Announc. 3:e00859-e00815(2015).
RN [2] {ECO:0000313|Proteomes:UP000036399}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PBH53 {ECO:0000313|Proteomes:UP000036399};
RA Gosse J.T., Boddy C.N., Hill P.B.;
RT "Draft Genome Sequence of Streptomyces sp. strain PBH53, isolated from
RT urban environment.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-
CC cysteine + H(+) + phosphate; Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00029283};
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DR EMBL; CP011799; AKN70920.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0H4C250; -.
DR STRING; 1577075.QR97_14845; -.
DR PATRIC; fig|1577075.3.peg.3050; -.
DR Proteomes; UP000036399; Chromosome.
DR GO; GO:0004357; F:glutamate-cysteine ligase activity; IEA:InterPro.
DR GO; GO:0042398; P:cellular modified amino acid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.590.20; -; 1.
DR InterPro; IPR006336; GCS2.
DR InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR Pfam; PF04107; GCS2; 1.
DR SUPFAM; SSF55931; Glutamine synthetase/guanido kinase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000036399}.
SQ SEQUENCE 173 AA; 17839 MW; 2D7777597E3D3C20 CRC64;
MSIASAAPSL SPAELRSVFE RNTQDELVGI EIESAALDPR TGRSIPYAGE SGIGAYLAFL
ASQPGVEAVH DYGTLVGVRL PDGGQVSLEH GGAVEYSSPP APCVADLMDL VHAALRRLAA
AADRFGFALV PGRSTRARPS RTSSGCRTPV RRSCAATSRA WAGTACGARG SCP
//
